CAPSULE-TYPE DRUG-RELEASING DEVICE AND CAPSULE-TYPE DRUG-RELEASING DEVICE SYSTEM

• US 20070071807A1
• Filed: 09/28/2006
• Published: 03/29/2007
• Est. Priority Date: 09/28/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/536,194
• Publication Number:
  US 20070071807A1
• Time in Patent Office: Days
• US Class Current: 424/451
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61K 9/48 Preparations in capsules, e.g. of gelatin, of chocolate A61K9/0004 takes precedence; bite capsules A61K9/0056

Abstract

A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.

Claims

1. A capsule-type drug release apparatus, comprising:

a housing in a shape of a capsule;

a first ion exchange member capable of selectively passing an ion of a first polarity therethrough, the first ion exchange member being disposed on a surface of the housing in the shape of a capsule;

a drug solution holding portion disposed in the housing and inside the first ion exchange member for holding a drug ion of the first polarity;

a second ion exchange member disposed further inside the drug solution holding portion, the second ion exchange member being capable of selectively passing an ion of a second polarity therethrough, the second polarity different from the first polarity;

an electrolyte solution holding portion disposed further inside the second ion exchange member;

electrodes disposed further inside the electrolyte solution holding portion;

an electric power source connected to the electrodes;

a control portion capable of controlling energization/disenergization from the electric power source to the electrodes; and

a receiving portion where the control portion receives a signal from the outside of an organism.

2. The capsule-type drug release apparatus according to claim 1, further comprising a transmitting portion capable of transmitting a signal from the control portion to the outside of the organism.

3. The capsule-type drug release apparatus according to claim 1, wherein each of the ion exchange members is formed of an ion exchange membrane.

4. The capsule-type drug release apparatus according to claim 3, further comprising a transmitting portion capable of transmitting a signal from the control portion to the outside of the organism.

5. A capsule-type drug release apparatus system, characterized by comprising:

a capsule-type drug release apparatus comprising at least

a housing in a shape of a capsule,

a first ion exchange member capable of selectively passing an ion of a first polarity therethrough, the first ion exchange member being disposed on a surface of the housing in the shape of a capsule,

a drug solution holding portion disposed in the housing and inside the first ion exchange member for holding a drug ion of the first polarity,

a second ion exchange member disposed further inside the drug solution holding portion, the second ion exchange member being capable of selectively passing an ion of a second polarity therethrough,

an electrolyte solution holding portion disposed further inside the second ion exchange member,

electrodes disposed further inside the electrolyte solution holding portion,

an electric power source connected to the electrodes,

a control portion capable of controlling energization from the electric power source to the electrodes, and

a receiving portion where the control portion receives a signal from the outside of an organism;

position determining means capable of determining a position of the capsule-type drug release apparatus in the organism; and

transmitting means capable of transmitting a signal from the outside of the organism, the signal being received by the receiving portion.

6. The capsule-type drug release apparatus system according to claim 5 wherein

the capsule-type drug release apparatus further comprises a transmitting portion capable of transmitting a signal from the control portion to the outside of the organism, and

the capsule-type drug release apparatus system further comprises receiving means capable of receiving a signal outside the organism, the signal being transmitted by the transmitting portion.