Combination therapy for treating alphavirus infection and liver fibrosis
First Claim
1. A method of treating a hepatitis virus infection in an individual, the method comprising administering to the individual an effective amount of interferon alpha (IFN-α
- ) and an effective amount of pirfenidone or a pirfenidone analog.
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Abstract
The present invention provides methods for treating alphavirus infections; methods of treating hepatitis C virus (HCV) infections; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with HCV and cirrhosis of the liver; and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from viral infection. The methods generally involve administering effective amounts of an interferon receptor agonist and pirfenidone in combination therapy.
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Citations
12 Claims
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1. A method of treating a hepatitis virus infection in an individual, the method comprising administering to the individual an effective amount of interferon alpha (IFN-α
- ) and an effective amount of pirfenidone or a pirfenidone analog.
- View Dependent Claims (2, 3, 4)
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5. A method of treating an alphaviral infection in an individual, the method comprising administering to the individual an effective amount of an interferon-alpha (IFN-α
- ) and an effective amount of pirfenidone or a pirfenidone analog.
- View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
Specification