Method and system for analysis of cancer biomarkers using proteome image mining
First Claim
1. A system of analyzing cancers using a proteome image mining tool, comprising:
- input means for inputting serum proteome;
proteome standard production means for generating a proteome standard by transforming received serum proteome from a plurality of normal and diseased individuals into two-dimensional images and extracting spots as cancer-specific features from the images, and distinguishing optimal feature data among the extracted feature data, and transforming serum proteome of a subject into a two-dimensional image and extracting features from the image;
proteome comparison means for mapping the serum proteome pattern of the subject, extracted by the proteome standard production means, with the proteome standard pattern to determine similarity between the two patterns;
disease analysis means for estimating the serum proteome of the subject as ‘
normal’
if the serum proteome pattern of the subject would be similar to that of the normal individuals, and otherwise, as ‘
having cancer’
, based on the mapping results by the proteome comparison means; and
output means for outputting the analysis results by the disease analysis means.
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Abstract
The present invention provide a system and a method for detection of cancer, by producing a serum proteome standard by an image mining technique, and provide cancer-specific biomarkers. Disclosed is a method of analyzing cancer, comprising the steps of transforming serum proteomes from normal individuals and individuals having cancer into two-dimensional images, and constructing a database consisting of the proteome standard by an image mining technique; inputting a serum proteome from a subject of interest, transforming the serum proteome into a image and comparing the structure of the serum proteome pattern of the subject with the proteome standard and determining whether the serum proteome of the subject is normal or abnormal. The system and method for cancer analysis facilitates detection of cancer by constructing a database from a plurality of serum proteome using an image technique and comparing serum proteome of a subject with a proteome standard.
22 Citations
22 Claims
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1. A system of analyzing cancers using a proteome image mining tool, comprising:
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input means for inputting serum proteome;
proteome standard production means for generating a proteome standard by transforming received serum proteome from a plurality of normal and diseased individuals into two-dimensional images and extracting spots as cancer-specific features from the images, and distinguishing optimal feature data among the extracted feature data, and transforming serum proteome of a subject into a two-dimensional image and extracting features from the image;
proteome comparison means for mapping the serum proteome pattern of the subject, extracted by the proteome standard production means, with the proteome standard pattern to determine similarity between the two patterns;
disease analysis means for estimating the serum proteome of the subject as ‘
normal’
if the serum proteome pattern of the subject would be similar to that of the normal individuals, and otherwise, as ‘
having cancer’
, based on the mapping results by the proteome comparison means; and
output means for outputting the analysis results by the disease analysis means. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of analyzing cancer diseases using a proteome image mining tool, comprising the steps of:
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transforming inputted serum proteomes from normal individuals and individuals having cancer into two-dimensional images, extracting feature data from the images, generating a proteome standard by computing optimal features from the feature data, and constructing a database consisting of the proteome standard (Step
1);
inputting a serum proteome from a subject of interest, transforming the serum proteome into a two-dimensional image and extracting feature data from the image (Step
2); and
comparing the structure of the serum proteome pattern of the subject with the proteome standard and determining whether the serum proteome of the subject is normal or abnormal, that is, indicative of cancer (Step
3). - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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- 21. (A) A biomarkers or biomarkers for diagnosis of cancers, comprising a proteome pattern, wherein said proteome pattern is one or more selected from spots listed in Table 1.
Specification