Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
First Claim
1. A method of identifying an individual having an altered risk for developing an acute coronary event or a method of evaluating an individual'"'"'s likelihood of responding to statin treatment, comprising detecting the presence or absence of one or more alleles of a SNP in said individual'"'"'s nucleic acids, wherein the SNP is selected from any one of the nucleotide sequences of SEQ ID NOS:
- 121-200 and SEQ ID NOS;
251-410, and the presence or absence of the alleles are correlated with an individual'"'"'s risk for developing an acute coronary event or likelihood of responding to statin treatment.
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Accused Products
Abstract
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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Citations
27 Claims
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1. A method of identifying an individual having an altered risk for developing an acute coronary event or a method of evaluating an individual'"'"'s likelihood of responding to statin treatment, comprising detecting the presence or absence of one or more alleles of a SNP in said individual'"'"'s nucleic acids, wherein the SNP is selected from any one of the nucleotide sequences of SEQ ID NOS:
- 121-200 and SEQ ID NOS;
251-410, and the presence or absence of the alleles are correlated with an individual'"'"'s risk for developing an acute coronary event or likelihood of responding to statin treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 121-200 and SEQ ID NOS;
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8. A method of detecting a single nucleotide polymorphism (SNP) in a nucleic acid molecule, comprising contacting a test sample with a reagent which specifically hybridizes to a SNP in any one of the nucleotide sequences of SEQ ID NOS:
- 1-60 and 121-410 under stringent hybridization conditions, and detecting the formation of a hybridized duplex.
- View Dependent Claims (9)
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10. A method of identifying an individual having an altered risk for developing an acute coronary event or a method of evaluating an individual'"'"'s likelihood of responding to statin treatment, comprising detecting the presence or absence of a polymorphism in said individual'"'"'s nucleic acids, wherein said polymorphism is in linkage disequilibrium with a SNP in any one of the nucleotide sequences of SEQ ID NOS:
- 121-200 and SEQ ID NOS;
251-410, and the presence or absence of the polymorphism is correlated with an individual'"'"'s risk for developing an acute coronary event or likelihood of responding to statin treatment. - View Dependent Claims (11)
- 121-200 and SEQ ID NOS;
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12. A method of treating a cardiovascular disorder in an individual, comprising administering to said individual an effective amount of statin based on said individual'"'"'s likelihood of responding to statin treatment, as predicted by the presence or absence of a SNP selected from the group consisting of SNPs disclosed in Tables 1-2.
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13. A reagent for detecting a variant protein encoded by a SNP-containing nucleic acid molecule, said reagent selectively binds to the variant protein as compared to a protein encoded by another nucleic acid molecule, wherein the SNP-containing nucleic acid molecule contains a SNP in any one of the nucleotide sequences of SEQ ID NOS:
- 121-200 and SEQ ID NOS;
251-410. - View Dependent Claims (14, 15, 16)
- 121-200 and SEQ ID NOS;
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17. An amplified polynucleotide containing a single nucleotide polymorphism (SNP) selected from any one of the nucleotide sequences of SEQ ID NOS:
- 1-60 and 121-410, or a complement thereof, wherein the amplified polynucleotide is between about 16 and about 1,000 nucleotides in length.
- View Dependent Claims (18)
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19. An isolated polynucleotide which specifically hybridizes to a nucleic acid molecule containing a single nucleotide polymorphism (SNP) in any one of the nucleotide sequences in SEQ ID NOS:
- 1-60 and 121-410.
- View Dependent Claims (20, 21, 22, 23)
- 24. An isolated polypeptide comprising of an amino acid sequence selected from the group of amino acid sequences consisting of SEQ ID NOS:
Specification