Low-loss multi-lumen injection apparatus

• US 20070073267A1
• Filed: 01/23/2006
• Published: 03/29/2007
• Est. Priority Date: 09/27/2005
• Status: Abandoned Application

• Current Assignee: Mile Creek Capital LLC
• Original Assignee: Mile Creek Capital LLC
• Inventors: Muller, David
• Application Number:
  US11/337,788
• Publication Number:
  US 20070073267A1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2005/1787 Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
• CPC Class Codes: A61M 2005/31598 having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
• CPC Class Codes: A61M 2005/3201 Coaxially assembled needle cannulas placed on top of another, e.g. needles having different diameters
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/3297 Needles arranged coaxially

Abstract

Injection devices, systems and methods are disclosed for injecting two or more medicaments to a patient at a single injection site while preferably minimizing any mixing of the medicaments prior to delivery to the patient. The invention can also be used to sequentially deliver the medicaments to the patient in a repetitive manner. For example, the injection apparatus can sequentially provide a first medicament and then a second medicament to the patient during a first injection procedure. During a second injection procedure, the injection apparatus can again sequentially provide the first medicament and the second medicament to the patient either at the injection site of the first injection procedure or at a different injection site. Multi-lumen manifolds are disclosed for coupling to conventional drug ampoules, to permit the user to sequentially delivery different medicaments via a single skin penetration and to reduce losses associated with usage. Systems including multiple drug reservoirs and filling adaptors are also disclosed.

Claims

1. An injection manifold for delivering a plurality of medicaments, the apparatus comprising:

a manifold body;

at least one hypodermic needle adapted to penetrate skin; and

at least two lumens disposed within the manifold body to provide fluidic coupling between separate medicament sources and a target tissue site, each lumen having an associated actuator to dispense a medicament,

wherein at least one lumen and its associated actuator are configured to dispense medicament with substantially no residual volume.

2. The injection manifold of claim 1 wherein at least one lumen has an associated actuator that further comprises a plunger slidable disposed within the lumen for longitudinal movement to dispense medicament from a distal end of the lumen.

3. The injection manifold of claim 2 wherein the plunger and lumen are configured such that when a medicament is dispensed from the lumen and the plunger has reached the distal end of the lumen, the residual volume of medicament within the manifold is less than 10 microliters.

4. The injection manifold of claim 3 wherein the residual volume is less than 5 microliters.

5. The injection manifold of claim 3 wherein the residual volume is less than 1 microliters.

6. The injection manifold of claim 1 wherein the hypodermic needle is single lumen needle.

7. A method for delivering a plurality of medicaments, the method comprising:

disposing an injection apparatus adjacent to a target skin region;

penetrating the skin region with the injection apparatus;

applying a first medicament using the injection apparatus;

applying a second medicament using the injection apparatus; and

repeating the steps of applying the first medicament and applying the second medicament using the injection apparatus,

at least one of said medicaments being applied via a manifold that has substantially no residual volume.

8. A method for delivering a plurality of medicaments, the method comprising:

disposing a multi-lumen injection apparatus adjacent to a target skin region, the injection apparatus having a manifold body, at least one hypodermic needle adapted to penetrate skin; and

at least two lumens disposed within the manifold body containing separate medicament sources, each lumen having an associated actuator to dispense a medicament, and wherein at least one lumen and its associated actuator are configured to dispense medicament with substantially no residual volume;

penetrating the skin region with the injection apparatus;

applying one medicament; and

applying other medicament.

9. The method of claim 8 wherein the method further comprises penetrating the skin to an initial depth and releasing one medicament and then penetrating to a different depth and release another medicament.

10. The method of claim 8 wherein the method further comprises sequentially applying at least two different medicaments from the first and second reservoirs repeatedly at a same location.

11. The method of claim 8 wherein the method further comprises repeating the application of the at least two different medicaments from the first and second reservoirs at a different location.

12. The method of claim 8 wherein one medicament is an anesthetic agent and the method further comprises initially applying the anesthetic agent from one of the reservoirs.