Method and apparatus for regulating a cardiac stimulation therapy

• US 20070073352A1
• Filed: 09/28/2005
• Published: 03/29/2007
• Est. Priority Date: 09/28/2005
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Manda, Ven, Bennett, Tommy, Euler, David, Deno, D., Splett, Vincent
• Application Number:
  US11/237,177
• Publication Number:
  US 20070073352A1
• Time in Patent Office: Days
• US Class Current: 607/23
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

A method comprising sensing a blood pressure signal, deriving a hemodynamic measure from the sensed blood pressure signal, adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and delivering extra systolic stimulation pulses according to the adjusted control parameter. The sensed blood pressure signal may be a ventricular or arterial blood pressure signal from which an estimated cardiac output, end diastolic pressure, mean pressure or any other hemodynamic measure is derived. Adjusting the extra systolic stimulation control parameter may include adjusting a pacing rate, a pacing interval, an extra systolic stimulation ratio, an extra systolic stimulation interval or enabling or terminating the extra systolic stimulation.

Claims

1. A method, comprising:

sensing a blood pressure signal;

deriving a hemodynamic measure using the sensed blood pressure signal,

adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and

delivering extra systolic stimulation pulses according to the adjusted control parameter.

2. The method of claim 1, wherein sensing the blood pressure signal includes sensing a ventricular blood pressure signal.

3. The method of claim 1 wherein deriving the hemodynamic measure includes deriving an estimated cardiac output using the sensed blood pressure signal.

4. The method of claim 3 wherein deriving the estimated cardiac output includes computing a pulse contour integral using the blood pressure signal

5. The method of claim 1 wherein deriving the hemodynamic measure includes estimating a flow contour using the blood pressure signal.

6. The method of claim 1 wherein deriving the hemodynamic measure includes deriving an estimated end diastolic pressure.

7. The method of claim 1 wherein deriving the hemodynamic measure includes deriving an estimated mean arterial pressure.

8. The method of claim 1 wherein adjusting the extra systolic stimulation control parameter includes adjusting a parameter for enabling or terminating the delivery of extra systolic stimulation pulses.

9. The method of claim 1 wherein adjusting the extra systolic stimulation control parameter includes adjusting any of:

a pacing rate, a pacing interval, an extra systolic stimulation interval, and an extra systolic stimulation ratio.

10. The method of claim 1 wherein sensing the blood pressure signal includes sensing an arterial blood pressure signal.

11. A medical device, comprising:

a blood pressure sensor for sensing a blood pressure signal;

a signal processing module for deriving a hemodynamic measure from the sensed blood pressure signal;

a therapy delivery module for delivering extra systolic stimulation pulses;

a timing and control module for controlling the delivery of extra systolic stimulation pulses delivered by the therapy delivery module in response to the derived hemodynamic measure.

12. The medical device of claim 11 wherein the blood pressure sensor is adapted for deployment in the right ventricle.

13. The medical device of claim 11 wherein the blood pressure sensor is adapted for deployment in the pulmonary artery.

14. The medical device of claim 11 wherein the hemodynamic measure is an estimated cardiac output.

15. A medical device, comprising:

means for obtaining a blood pressure signal;

means for deriving a hemodynamic measure using the blood pressure signal;

means for adjusting an extra systolic stimulation control parameter in response to the derived hemodynamic measure;

means for delivering extra systolic stimulation pulses according to the extra systolic stimulation control parameter.

16. The device of claim 15, wherein the means for obtaining a blood pressure signal includes means for sensing a ventricular pressure.

17. The device of claim 15, wherein the means for obtaining a blood pressure signal includes means for sensing an arterial pressure.

18. The device of claim 15, wherein the means for deriving a hemodynamic measure includes means for computing a pulse contour integral using the blood pressure signal.

19. The device of claim 15 wherein the means for deriving a hemodynamic measure includes means for estimating a mean arterial pressure.

20. The device of claim 15 wherein the means for deriving a hemodynamic measure includes means for estimating an end diastolic pressure.

21. The device of claim 15 wherein the means for adjusting an extra systolic stimulation control parameter includes means for adjusting any of:

a pacing rate, an extra systolic stimulation ratio, a pacing interval, and an extra systolic interval.

22. The device of claim 15 wherein the means for adjusting an extra systolic stimulation control parameter includes means for enabling or disabling the means for delivering extra systolic stimulation pulses.

23. The device of claim 15 wherein the means for delivering extra systolic stimulation pulses includes means for weaning extra systolic stimulation pulses.

24. The device of claim 23 wherein the means for weaning extra systolic stimulation pulses includes means for progressively increasing any of:

an extra systolic stimulation ratio and an extra systolic stimulation interval.

25. A computer readable medium for storing a set of instructions which when implemented in a system cause the system to:

acquire a blood pressure signal;

derive a hemodynamic measure using the blood pressure signal;

adjust an extra systolic stimulation control parameter in response to the derived hemodynamic measure; and

deliver extra systolic stimulation pulses according to the extra systolic stimulation control parameter.

26. The computer readable medium of claim 25 wherein the blood pressure signal is a ventricular blood pressure signal.

27. The computer readable medium of claim 25 wherein the blood pressure signal is an arterial signal.

28. The computer readable medium of claim 25 wherein the derived hemodynamic measure is an estimated cardiac output.

29. The computer readable medium of claim 25 wherein deriving a hemodynamic measure includes performing a pulse contour analysis of the blood pressure signal.

30. The computer readable medium of claim 25 wherein deriving a hemodynamic measure includes performing a flow contour estimation using the blood pressure signal.

31. The computer readable medium of claim 25 wherein the extra systolic stimulation control parameter is any of:

a pacing rate, an extra systolic stimulation ratio, a pacing interval, and an extra systolic stimulation interval.

32. The computer readable medium of claim 25 wherein the extra systolic stimulation control parameter is a parameter that enables or terminates extra systolic stimulation pulses.

33. The computer readable medium of claim 32 further including instructions which cause the system to perform a weaning procedure when extra systolic stimulation is terminated.

34. The computer readable medium of claim 33 wherein the weaning procedure includes progressively adjusting any of:

an extra systolic stimulation ratio, and an extra systolic stimulation interval.