Drug-eluting stent cover and method of use
First Claim
1. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
- an intravascular stent configured to contact the walls of the body lumen to maintain the patency of the vessel; and
a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh stent cover is configured of a random mesh pattern, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent.
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Accused Products
Abstract
An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
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Citations
28 Claims
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1. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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an intravascular stent configured to contact the walls of the body lumen to maintain the patency of the vessel; and
a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh stent cover is configured of a random mesh pattern, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent. - View Dependent Claims (2, 3, 4)
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6. The stent system of claim 5, wherein the polymeric stent mesh cover is fabricated from a polymeric material selected from the group consisting of PMMA, EVAL, PBMA, PGA, PEG, HA, PEA, PGS and PLLA.
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7. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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a stent structure comprising a pattern of interconnected struts that contacts the walls of the body lumen to maintain the patency of the vessel; and
a stent cover defining a delivery sheath fabricated as a metallic or ceramic prepatterned sheet having a polymer layer disposed thereon, the stent cover being loaded with at least one therapeutic drug for the release thereof at a treatment site, the stent cover being attached to at least a portion of an outside surface area of the stent structure. - View Dependent Claims (8, 9, 10, 11)
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12. A stent system for delivery of a therapeutic agent in a blood vessel, comprising:
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a pattern of struts interconnected to form a stent structure that contacts the walls of a body lumen to maintain the patency of the vessel; and
a stent cover defining a delivery sheath fabricated from a mesh with a web pattern placed over the stent being attached to at least a portion of an outside surface area of the stent structure, the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof in the vessel, wherein the web pattern includes weakened points at selected locations to provide nonrandom breakage during expansion, the mesh cover being held against the vessel wall by the stent structure. - View Dependent Claims (13, 14, 15, 16)
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17. A stent system for deployment in a blood vessel, comprising:
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an intravascular stent configured to contact the walls of a vessel to maintain the patency of the vessel; and
a stent cover defining a sheath fabricated from a mesh placed over the stent, the stent cover includes one or more positions that will break during expansion in a vessel.
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18. A drug-containing stent system for deployment in a body lumen, comprising:
a mesh structure containing at least one drug, the mesh structure including individual mesh members, at least one individual mesh member including a breakable point that will break during expansion to allow unbroken mesh members to deploy against a body lumen as the mesh further expands. - View Dependent Claims (19, 20, 21)
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22. A drug-containing stent system for deployment in a blood vessel, comprising:
a mesh structure containing at least one drug, the mesh structure including mesh members, and breakable means for connecting at least some of the mesh members such that the breakable means break in a blood vessel during expansion to allow unbroken mesh members to deploy against the blood vessel.
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23. A stent system for delivery of a therapeutic agent in a blood vessel, comprising:
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a pattern of struts interconnected to form a stent structure that contacts the walls of a body lumen to maintain the patency of the vessel; and
a stent cover defining a delivery sheath fabricated from a mesh with a web pattern placed over the stent being attached to at least a portion of an outside surface area of the stent structure, the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof in the vessel, wherein upon expansion of the stent, the mesh stent cover is necked down, the mesh cover being held against the vessel wall by the stent structure. - View Dependent Claims (24, 25, 26, 27, 28)
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Specification