Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings

• US 20070073390A1
• Filed: 09/23/2005
• Published: 03/29/2007
• Est. Priority Date: 09/23/2005
• Status: Abandoned Application

• Current Assignee: Medlogics Device Corporation
• Original Assignee: Medlogics Device Corporation
• Inventors: Lee, Michael
• Application Number:
  US11/233,965
• Publication Number:
  US 20070073390A1
• Time in Patent Office: Days
• US Class Current: 623/1.460
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/121 having an inorganic matrix
• CPC Class Codes: B05D 1/007 using an electrostatic field B05D1/02 - B05D1/16 take precedence
• CPC Class Codes: B05D 2350/65 metal layer
• CPC Class Codes: B05D 7/16 using synthetic lacquers or varnishes
• CPC Class Codes: C23C 18/165 Multilayered product layered product B32B
• CPC Class Codes: C23C 18/1662 Use of incorporated material in the solution or dispersion, e.g. particles, whiskers, wires
• CPC Class Codes: C23C 18/1841 with use of metal first
• CPC Class Codes: C23C 18/32 Coating with nickel, cobalt or mixtures thereof with phosphorus or boron C23C18/50 takes precedence
• CPC Class Codes: C23C 28/00 Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
• CPC Class Codes: C23C 28/023 only coatings of metal elements only
• CPC Class Codes: C25D 15/00 Electrolytic or electrophoretic production of coatings containing embedded materials, e.g. particles, whiskers, wires
• CPC Class Codes: C25D 15/02 Combined electrolytic and electrophoretic processes with charged materials
• CPC Class Codes: C25D 5/48 After-treatment of electroplated surfaces

Abstract

Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures with enhanced adhesion characteristics. The bioactive composite structures are prepared using anchors that are electrochemically codeposited into a metallic layer that is formed on the surface of implantable medical device followed by the adhesion of a bioactive material-containing coating to the substrate and anchors.

Claims

1. A method comprising:

providing a solution comprising metal ions and anchors;

contacting a substrate with said solution thereby forming a metallic composite structure through an electrochemical process wherein at least a subset of said anchors are exposed on at least a portion of the surface of said structure; and

adhering a bioactive material-containing coating to said surface of said structure and said exposed anchors wherein said bioactive material-containing coating and said anchors have physical characteristics that are more similar than the physical characteristics of said bioactive material coating and said substrate.

2. The method according to claim 1, wherein said anchors include a bioactive material and said formed structure is a bioactive composite structure.

3. The method according to claim 1, wherein said anchors are free of bioactive materials and said formed structure is a composite structure.

4. The method according to claim 1, wherein said electrochemical process is selected from the group consisting of an electrolytic codeposition process, an electroless codeposition process and an electrophoretic codeposition process.

5. The method according to claim 1, wherein said anchors comprise a polymer.

6. The method according to claim 1, wherein said bioactive material-containing coating comprises a polymer.

7. The method according to claim 1, wherein said anchors and said bioactive material-containing coating both comprise a polymer.

8. The method according to claim 1, wherein said anchors and said bioactive material-containing coating are only applied to a portion of substrate.

9. The method of claim 1, wherein said substrate is a stent.

10. The method of claim 1, further comprising forming a topcoat over said adhered bioactive material-containing coating.

11. A medical device comprising:

a substrate having a metallic composite structure containing anchors wherein said structure is formed through an electrochemical process wherein at least a subset of said anchors are exposed on the surface of said structure; and

a bioactive material-containing coating adhered to said surface of said structure and said exposed anchors wherein said bioactive material-containing coating and said anchors have physical characteristics that are more similar than the physical characteristics of said bioactive material coating and said substrate.

12. The medical device according to claim 11, wherein said anchors include a bioactive material and said formed structure is a bioactive composite structure.

13. The medical device according to claim 11, wherein said anchors are free of bioactive materials and said formed structure is a composite structure.

14. The medical device according to claim 11, wherein said electrochemical process is selected from the group consisting of an electrolytic codeposition process, an electroless codeposition process and an electrophoretic codeposition process.

15. The medical device according to claim 11, wherein said bioactive material-containing coating comprises a polymer.

16. The medical device according to claim 11, wherein said anchors and said bioactive material-containing coating both comprise a polymer.

17. The medical device according to claim 11, wherein said anchors and said bioactive material-containing coating are only applied to a portion of substrate.

18. The medical device according to claim 11, wherein said substrate is a stent.

19. The medical device according to claim 11, further comprising a topcoat over said adhered bioactive material-containing coating.