Compact analyzer for dry biochemical analysis of blood samples

• US 20070077173A1
• Filed: 10/03/2006
• Published: 04/05/2007
• Est. Priority Date: 10/03/2005
• Status: Abandoned Application

• Current Assignee: Francois Melet
• Original Assignee: Francois Melet
• Inventors: Melet, Francois
• Application Number:
  US11/541,555
• Publication Number:
  US 20070077173A1
• Time in Patent Office: Days
• US Class Current: 422/64
• CPC Class Codes: G01N 2021/3133 with selection of wavelengths before the sample
• CPC Class Codes: G01N 2021/3166 using separate detectors and filters
• CPC Class Codes: G01N 2021/3177 Use of spatially separated filters in simultaneous way
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 2201/0415 Carrusel, sequential
• CPC Class Codes: G01N 2201/06186 Resistance heated; wire sources; lamelle sources
• CPC Class Codes: G01N 2201/12792 Compensating own radiation in apparatus
• CPC Class Codes: G01N 2201/1285 Standard cuvette
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes

Abstract

A compact analyzer for dry biochemical analysis of blood samples, integrating onto a common chassis (11):

• • a measuring chamber (20) adapted to receive a disposable rotor (13) including microtanks (13A, 13B) containing dry reagents,
  • a digital dilution module (21) of fixed or variable ratio defined as a function of the species of the sample to be analyzed,
  • a sample centrifuging module (12) adapted, inside the measuring chamber, to centrifuge the rotor and position it angularly,
  • an optical module adapted to apply beams of light to microtanks of the rotor, this optical module including a flash-lamp type light source (14) and a reference light sensor (16),
  • an electronic processing and control system (23, 24, 25) including an external memory reader (26) adapted to read a portable external memory (27) containing at least information characteristic of at least the disposable rotor in use.

Claims

1. Compact analyzer for dry biochemical analysis of blood samples, integrating onto a common chassis (11):

a measuring chamber (20) adapted to receive a disposable rotor (13) including at least one diluted sample receiving central chamber (13′

) and, around that central chamber, a plurality of microtanks (13A, 13B) containing dry reagents and adapted to receive fluid from that central chamber during centrifuging of this rotor,

a digital dilution module (21) of fixed or variable ratio defined as a function of the species of the sample to be analyzed and adapted to dispose a diluted sample into a central chamber of this rotor from a blood sample (22) from a given species,

a sample centrifuging module (12) adapted, inside the measuring chamber, to centrifuge the rotor and position it angularly at a plurality of angular positions,

an optical module adapted to apply beams of light to the interior of the measuring chamber, in areas that may be occupied by microtanks of the rotor, in at least some of said angular positions of the rotor, this optical module including a flash-lamp type light source (14) and a reference light sensor (16),

an electronic processing and control system (23, 24, 25) for controlling the dilution module, the optical module and the centrifuging module, to acquire measurements from the beams intercepted by said areas of the measuring chamber, to process these measurements and to deduce results therefrom, said processing system including an external memory reader (26) adapted to read a portable external memory (27) containing at least information characteristic of at least the disposable rotor in use.

2. Analyzer according to claim 1, characterized in that the external memory contains information concerning the calibration of the rotor and the expiry date of the dry reagents contained in this rotor.

3. Analyzer according to claim 1, characterized in that the external memory further contains information, updated by the electronic processing system, on the use of the rotor in use.

4. Analyzer according to claim 3, characterized in that the external memory contains information, updated by the electronic processing system, on the numbers of tests that have been effected with the respective dry reagents.

5. Analyzer according to claim 4, characterized in that the external memory contains information, updated by the electronic processing system, on the number of tests that can still be effected with the dry reagents.

6. Analyzer according to claim 3, characterized in that the external memory contains information, updated by the electronic processing system, on tests effected and requested and on tests effected but not requested.

7. Analyzer according to claim 1, characterized in that the external memory contains information characteristic of a batch of disposable rotors.

8. Analyzer according to claim 1, characterized in that the external memory is a microcircuit card.

9. Analyzer according to claim 1, characterized in that the external memory is a Compact Flash type card.

10. Analyzer according to claim 1, characterized in that the external memory is a USB key.

11. Analyzer according to claim 1, characterized in that the digital diluter includes a piston actuated by a motor, this piston and this motor being mounted on the chassis, and a manipulation handle provided with a sampling and injection nozzle, which enables dilution of the sample to be analyzed to a ratio defined as a function of the species of the sample to be analyzed.

12. Analyzer according to claim 1, characterized in that the centrifuging module includes an eccentric stepper motor, pinions fixed to the shaft of this motor and to a drive shaft carrying the rotor in use and a belt cooperating with these pinions.

13. Analyzer according to claim 1, characterized in that the reference light sensor (16) is mounted, inside the optical module, on a beam splitter (17).

14. Analyzer according to claim 1, characterized in that the optical module includes a monochromator, optionally a filter wheel (18).

15. Analyzer according to claim 1, characterized in that the electronic control system includes input means for entering the species to which the blood sample belongs, and activates the dilution module as a function of that input.

16. Analyzer according to claim 1, characterized in that the electronic control system includes input means for entering individual tests to be effected in the rotor in use.

17. Analyzer according to claim 1, characterized in that it includes a module (19) for regulating the temperature of the measuring chamber (20) to a precise and stable temperature by means of pulsed air and a Peltier system.

18. Analyzer according to claim 2, characterized in that the external memory further contains information, updated by the electronic processing system, on the use of the rotor in use.

19. Analyzer according to claim 18, characterized in that the external memory contains information characteristic of a batch of disposable rotors.

20. Analyzer according to claim 19, characterized in that the digital diluter includes a piston actuated by a motor, this piston and this motor being mounted on the chassis, and a manipulation handle provided with a sampling and injection nozzle, which enables dilution of the sample to be analyzed to a ratio defined as a function of the species of the sample to be analyzed.