Article tissue systems and uses thereof

• US 20070077265A1
• Filed: 11/05/2004
• Published: 04/05/2007
• Est. Priority Date: 11/07/2003
• Status: Active Grant

• Current Assignee: University of Connecticut (State of Connecticut)
• Original Assignee: University of Connecticut (State of Connecticut)
• Inventors: Kreutzer, Donald, Klueh, Ulrike, Dorsky, David
• Granted Patent: US 8,916,184 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: C12N 5/0062 General methods for three-dimensional culture

Abstract

An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS-device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATS-device combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in vivo uses.

Claims

1. An artificial tissue system, comprising:

(a) a matrix configured for biological contact with an implantable device, and

(b) a plurality of cells supported by said matrix, said cells promoting a biological interaction between said implantable device and a biological system.

2. The artificial tissue system of claim 1, wherein said cells include at least one member selected from the group consisting of biological cells, engineered cells, support cells, stem cells, artificial cells and hybrid cells.

3. The artificial tissue system of claim 1, wherein said cells promote biocompatibility between said implantable device and said biological system.

4. The artificial tissue system of claim 1, wherein said cells enhance the lifespan and/or the function of said implantable device.

9. The artificial tissue system of claim 1, wherein said biological system comprises a mammal.

14. The artificial tissue system of claim 1, wherein said implantable device is a sensor.

15. The artificial tissue system of claim 14, wherein said sensor is a glucose sensor.

16. The artificial tissue system of claim 1, wherein said matrix is configured to at least partially embed said implantable device.

19. The artificial tissue system of claim 1, wherein said cells are configured to suppress deleterious reactions between said implantable device and said biological system and/or said artificial tissue system.

20. The artificial tissue system of claim 1, wherein said matrix comprises at least one member selected from the group consisting of biological matrices, engineered matrices, synthetic matrices, and hybrid matrices.

25. The artificial tissue system of claim 1, wherein said system further comprises a support system and/or a delivery system comprising a gel, a paste and/or a polymer.

27. An implant comprising an implantable device in biological contact with the artificial tissue system of claim 1.

36. A system for testing the effectiveness of an implant comprising the artificial tissue system of claim 1.

50. A system for compatibilizing an implant with an implant-receiving biological system comprising the artificial tissue system of claim 1.

51. The artificial tissue system of claim 1, wherein the matrix comprises a gel.

5-8. -8. (canceled)

10-13. -13. (canceled)

17-18. -18. (canceled)

21-24. -24. (canceled)

26. (canceled)

28. An implant system comprising:

(a) an implantable device,

(b) a matrix in biological contact with said implantable device, and

(c) a plurality of cells supported by said matrix, said cells promoting a biological interaction between said implantable device and a biological system.

52. The implant system of claim 28, wherein the matrix comprises a gel.

29. A method of implanting a device in a biological system, comprising the steps of:

(a) obtaining said device,

(b) obtaining a matrix,

(c) placing said device in biological contact with said matrix,

(d) inserting cells into said matrix, said cells being capable of promoting a biological interaction between said implantable device and said biological system, and

(e) implanting said matrix into said biological system.

32. The method of claim 29, wherein step (c) occurs after step (d) and before step (e).

35. The prolonged use of an implant formed by the method of claim 29, wherein additional cells are periodically inserted into said matrix during use of said implant.

53. The method of claim 29, wherein the matrix comprises a gel.

57. The method of claim 29, further comprising, before step (e), forming an implantation pocket in the biological system.

30-31. -31. (canceled)

33-34. -34. (canceled)

37. An artificial implant system in biological contact with a biological system comprising:

(a) a cellular component, said cellular component includes at least one cellular community which induces a biological response in the biological system;

(b) a matrix material, said matrix material being associated with a portion of the cellular community; and

(c) an implant device having a biological interface wherein said biological interface is associated with the matrix material and the biological system.

38. The artificial implant system in biological contact with a biological system of claim 37, wherein the biological response includes neovascularization.

39. The artificial implant system in biological contact with a biological system of claim 37, wherein the biological system is a mammal.

54. The artificial implant system of claim 37, wherein the matrix material comprises a gel.

59. The artificial implant system of claim 37, wherein the biological response includes inhibition of fibrosis.

40-49. -49. (canceled)

55-56. -56. (canceled)

58. (canceled)

60. An implant system comprising:

(a) an implantable device comprising a sensor, and

(b) a matrix comprising a gel in biological contact with said implantable device, said matrix promoting biocompatibility of said implantable device and a biological system.

61. A method of improving the biocompatibility of a sensor with a tissue system comprising placing a matrix comprising a gel between the sensor and the tissue system.

62. A method of implanting a device in a biological system, comprising:

(a) obtaining an implantable device,

(b) forming an implantation pocket in the biological system by injecting a biocompatible material, and

(b) implanting said implantable device in said implantation pocket.

63-65. -65. (canceled)