Compositions and methods for improved skin care

• US 20070077292A1
• Filed: 10/03/2006
• Published: 04/05/2007
• Est. Priority Date: 10/03/2005
• Status: Abandoned Application

• Current Assignee: Mark Pinsky
• Original Assignee: Mark Pinsky
• Inventors: Pinsky, Mark
• Application Number:
  US11/542,554
• Publication Number:
  US 20070077292A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/65 Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/735 Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1272 with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids with cholesterol as the only non-phosphatidyl surfactant A61K9/127; lipids as modifying agent A61K47/543
• CPC Class Codes: A61P 15/18 Feminine contraceptives
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/04 for chemically tanning the skin topical sun or radiation screening or tanning preparations A61Q17/04
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Compositions and methods for administering collagen to a human subject have been developed. The collagen-containing lipid vesicles of the invention provide a delivery system for human collagen which eliminates problems associated with chemical and physical instability of the collagen as well as immune responses to non-human collagen.

Claims

1. A liposome comprising at least one component selected from the group consisting of hyaluronic acid and collagen.

2. The liposome, according to claim 1, comprising hyaluronic acid.

3. The liposome, according to claim 2, wherein the hyaluronic acid is cross-linked.

4. The liposome, according to claim 2, wherein the hyaluronic acid is not cross-linked.

5. The liposome, according to claim 1, wherein the hyaluronic acid is linear hyaluronic acid of less than 500 kDa.

6. The liposome, according to claim 1, comprising collagen.

7. The liposome, according to claim 6, wherein the collagen is human collagen.

8. The liposome, according to claim 6, wherein the collagen is a recombinant collagen.

9. The liposome, according to claim 6, wherein said collagen is a collagen derivative.

10. The liposome, according to claim 6, wherein said collagen is a Type I or Type III collagen.

11. The liposome, according to claim 6, wherein said collagen is in a particle size of less than 800 nm.

12. The liposome, according to claim 6, wherein said collagen is in the fibril form.

13. The liposome, according to claim 1, which comprises collagen and hyaluronic acid.

14. The liposome, according to claim 1, further comprising at least one of the group consisting of desquamation agents, anti-acne agents, anti-wrinkle agents, vitamin B₃ compounds, retinoids, hydroxyl acids, anti-oxidants, radical scavengers, chelators, flavonoids, anti-inflammatory agents, anti-cellulite agents, topical anesthetics, tanning agents, skin lightening agents, skin soothing and skin healing agents, antimicrobial and antifungal agents, sunscreen agents, conditioning agents, structuring agents, thickening agent, and preservatives.

15. The liposome, according to claim 1, which is paucilamellar.

16. The liposome, according to claim 1, which comprises non-phospholipid surfactants.

17. A composition for delivering an agent into the skin of a subject wherein said composition comprises a cyclodextrin having associated therewith the agent, wherein the agent is selected from the group consisting of collagen and hyaluronic acid.

18. A method for administering an agent into the skin of a subject, the method comprising the step of contacting the skin of the subject with a composition comprising a carrier comprising a cavity having encapsulated therein an agent selected from the group consisting of collagen and hyaluronic acid, wherein said carrier is a liposome or a cyclodextrin.

19. The method, according to claim 18, wherein said carrier is a liposome.

20. The method, according to claim 19, wherein the liposome comprises hyaluronic acid.

21. The method, according to claim 19, wherein the liposome comprises collagen.

22. The method, according to claim 19, wherein the liposome further comprises at least one of the group consisting of desquamation agents, anti-acne agents, anti-wrinkle agents, vitamin B₃ compounds, retinoids, hydroxyl acids, anti-oxidants, radical scavengers, chelators, flavonoids, anti-inflammatory agents, anti-cellulite agents, topical anesthetics, tanning agents, skin lightening agents, skin soothing and skin healing agents, antimicrobial and antifungal agents, sunscreen agents, conditioning agents, structuring agents, thickening agent, and preservatives.

23. The method, according to claim 19, wherein the liposome is paucilamellar.