Process for providing antimicrobial surfaces
First Claim
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1. A process for providing a durable antimicrobial surface on a polymer substrate comprising:
- a) treating a polymer substrate with a first fluid comprising formaldehyde and a co-reactant selected from the group;
acid, anhydride, reactive halide, or mixtures thereof;
wherein the formaldehyde and co-reactant are present in amounts effective to provide a polymer substrate with a chemically modified surface; and
b) treating the chemically modified surface of step (a) with an antimicrobial fluid comprising an effective amount of an antimicrobial peptide sufficient to provide a durable antimicrobial surface.
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Abstract
Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.
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Citations
25 Claims
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1. A process for providing a durable antimicrobial surface on a polymer substrate comprising:
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a) treating a polymer substrate with a first fluid comprising formaldehyde and a co-reactant selected from the group;
acid, anhydride, reactive halide, or mixtures thereof;
wherein the formaldehyde and co-reactant are present in amounts effective to provide a polymer substrate with a chemically modified surface; and
b) treating the chemically modified surface of step (a) with an antimicrobial fluid comprising an effective amount of an antimicrobial peptide sufficient to provide a durable antimicrobial surface. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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2. A process for providing a durable antimicrobial surface on a polymer substrate comprising:
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a) (1) treating a polymer substrate with a first alternative fluid comprising formaldehyde and a hydroxymethylation catalyst wherein the formaldehyde and hydroxymethylation catalyst are present in an amount effective to provide a polymer substrate with a hydroxymethyl surface;
(2) treating the hydroxymethyl surface with a second alternative fluid comprising a reactant selected from the group;
acid, anhydride, reactive halide, and mixtures thereof;
in an amount effective to provide a polymer substrate with a chemically modified surface; and
b) treating the chemically modified surface of step (a) (2), with an antimicrobial fluid comprising an effective amount of an antimicrobial peptide sufficient to provide a durable antimicrobial surface. - View Dependent Claims (12, 15)
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Specification