Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
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Abstract
The present invention relates to optical bio-disc systems and related methods and to immobilizing receptor molecules. When a sample is injected into a fluidic circuit, the target agent binds to a capture probe bound in a capture zone. A signal is generated from tags attached to a reporter probe that has specific affinity to the target agent. The assays and methods of the present invention are implemented on an optical bio-disc. The optical bio-disc includes a flow channel having capture zones and in fluid communications with a mixing chamber, and a peripheral waste reservoir. The optical bio-disc is implemented on an optical bio-disc that has information encoding format such as CD. An disc drive assembly is employed to rotate the optical bio-disc, read and process any encoded information, and analyze the samples in the flow channel of the optical bio-disc.
74 Citations
127 Claims
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1-53. -53. (canceled)
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54. An optical bio-disc, comprising:
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a rotatable substrate having a center and an outer edge;
an outer reservoir formed in said substrate proximal to said outer edge;
an inner reservoir formed in said substrate proximal to and in fluid communication with said outer reservoir;
a channel layer positioned adjacent said substrate, said channel layer having at least one fluidic channel formed therein which is in fluid communication with said inner reservoir, thereby forming a fluidic circuit; and
a cap portion positioned adjacent said channel layer. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 126)
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72-125. -125. (canceled)
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127-136. -136. (canceled)
Specification