Iontophoretic delivery of vesicle-encapsulated active agents
First Claim
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1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
- an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising a plurality of first vesicles, at least some of the first vesicles encapsulating a first active agent.
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Abstract
An iontophoresis device is provided for the delivery of active agents encapsulated in vesicles such as transferosomes and niosomes to a biological interface such as skin or mucous membranes.
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Citations
28 Claims
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1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
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an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising a plurality of first vesicles, at least some of the first vesicles encapsulating a first active agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for transdermal administration of an active agent by iontophoresis, comprising:
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positioning an active electrode assembly and a counter electrode assembly of an iontophoresis device on a biological interface of a subject, the active electrode assembly further including an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising a plurality of vesicles, at least some of the vesicles encapsulating an active agent; and
applying a sufficient amount of current to administer a therapeutically effective amount of the active agent encapsulated in the vesicles in the subject for a limited period of time. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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Specification