SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN

• US 20070078500A1
• Filed: 09/29/2006
• Published: 04/05/2007
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: CorNova, Inc.
• Original Assignee: CorNova, Inc.
• Inventors: Tang, Jing, Ryan, S.
• Application Number:
  US11/537,258
• Publication Number:
  US 20070078500A1
• Time in Patent Office: Days
• US Class Current: 607/88
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body

Abstract

In a system and method for analyzing and treating a body lumen, a lumen-expanding balloon catheter with integrated one or more delivery waveguides and one or more collection waveguides is used to perform optical analysis of the tissues surrounding the lumen during expansion. The catheter can comprise an angioplasty catheter with integrated delivery waveguides and collection waveguides to perform spectroscopy of a stenotic plaque during angioplasty.

Claims

1. A catheter for placement within a body lumen, the catheter comprising:

a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers; and

a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon.

2. The catheter of claim 1 wherein the lumen-expanding balloon comprises an angioplasty balloon.

3. The catheter of claim 1 wherein the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide are contiguously retained to the flexible conduit.

4. The catheter of claim 3 further comprising a fiber holder disposed about the conduit that contiguously retains the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide to the flexible conduit.

5. The catheter of claim 4 wherein the fiber holder comprises at least one holder body having a plurality of holes that are substantially aligned with the longitudinal axis of the conduit when mounted thereto, the at least one delivery waveguide and the at least one collection waveguide being secured to the fiber holder at the holes.

6. The catheter of claim 4 wherein the fiber holder comprises at least one holder body having a plurality of grooves on a surface thereof, the at least one delivery waveguide and the at least one collection waveguide being secured to the fiber holder at the grooves.

7. The catheter of claim 6 wherein the plurality of grooves are arranged in a helix.

8. The catheter of claim 6 wherein the plurality of grooves are substantially aligned with the longitudinal axis of the conduit when the fiber holder is mounted thereto.

9. The catheter of claim 4 wherein the fiber holder is longitudinally translatable relative to the longitudinal axis of the flexible conduit so that the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide are translatable between a first longitudinal position and a second longitudinal position of the conduit.

10. The catheter of claim 4 wherein the fiber holder is rotatable about the longitudinal axis of the flexible conduit so that the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide can be rotated about the conduit.

11. The catheter of claim 1 wherein the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide are spaced apart at a predetermined distance in order to facilitate collection of radiation emitted from tissue of a predetermined depth from the lumen-expanding inflatable balloon through the transmission input.

12. The catheter of claim 1 wherein the at least one delivery waveguide comprises at least one delivery fiber optic and wherein the at least one collection waveguide comprises at least one collection fiber optic.

13. The catheter of claim 12 wherein the at least one delivery fiber optic has a tapered end that operates as a reflection surface for changing a direction of a path of radiation transmitted along a longitudinal axis of the delivery fiber optic so that the radiation is emitted in a direction that is transverse to the longitudinal axis of the fiber.

14. The catheter of claim 12 wherein the at least one collection fiber optic has a tapered end that operates as a reflection surface for changing a direction of a path of radiation transmitted into the transmission input of the collection fiber optic so that the radiation is transmitted along a longitudinal axis of the collection fiber optic.

15. The catheter of claim 1 further comprising an optical element disposed about the flexible conduit, the optical element including an array of multiple facets that lie at an acute angle relative to the longitudinal axis of the flexible conduit for changing a direction of radiation transmitted along a longitudinal axis of the at least one delivery waveguide so that the radiation is emitted in a direction that is transverse to the longitudinal axis of the at least one delivery waveguide.

16. The catheter of claim 1 further comprising an optical element disposed about the flexible conduit, the optical element including an array of multiple facets that lie at an acute angle relative to the longitudinal axis of the flexible conduit for changing a direction of radiation transmitted into the transmission input of the at least one collection waveguides so that the radiation is transmitted along longitudinal axes of the collection waveguides.

17. The catheter of claim 1 wherein distal ends of the at least one collection waveguides in the region of the transmission input lie along a helical path about the longitudinal axis of the conduit.

18. The catheter of claim 17 wherein distal ends of the at least one delivery waveguides in the region of the transmission output lie along a helical path about the longitudinal axis of the conduit.

19. The catheter of claim 18 wherein the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide are spaced apart at a predetermined distance in a longitudinal direction along the longitudinal axis of the conduit.

20. The catheter of claim 1 wherein the balloon comprises a polymer material that is substantially transparent to radiation at the wavelength in the range of about 250 to 2500 nanometers.

21. The catheter of claim 20 wherein the polymer material is selected from the group of materials consisting of nylon and polyethylene.

22. The catheter of claim 1 wherein the at least one delivery waveguide comprises a plurality of delivery waveguides and wherein the at least one collection waveguide comprises a plurality of collection waveguides.

23. The catheter of claim 22 wherein the at least one delivery waveguide comprises two, three or four delivery waveguides and wherein the at least one collection waveguide comprises two, three or four collection waveguides.

24. The catheter of claim 22 wherein the plurality of transmission outputs of the plurality of delivery waveguides are arranged to illuminate an interior wall of a lumen about a 360 degree portion thereof through the balloon, when the balloon is inflated within the lumen, and wherein the plurality of transmission inputs of the plurality of collection waveguides are arranged to receive radiation from the interior wall of the lumen about the illuminated 360 degree portion thereof through the balloon.

25. The catheter of claim 22 wherein the at least one delivery waveguide comprises first and second delivery waveguides and wherein the at least one collection waveguide comprises first and second collection waveguides, and wherein the transmission outputs of the first and second delivery waveguides are positioned circumferentially opposite each other relative to the flexible conduit and wherein the transmission inputs of the first and second collection waveguides are positioned circumferentially opposite each other relative to the flexible conduit, so that four quadrants of a 360 degree portion of an interior wall of the lumen can be illuminated by the radiation through the balloon and so that reflected radiation can be received from the four quadrants of the interior wall through the balloon.

26. The catheter of claim 1 wherein the transmission output of the at least one delivery waveguide comprises an uncladded fiber core sealed within a covering that is substantially transparent to radiation at the wavelength in the range of about 250 to 2500 nanometers.

27. The catheter of claim 26 wherein the substantially transparent covering comprises a cylindrical capsule containing a material having an index of refraction so as to provide an interface between the uncladded fiber core and the material in the capsule to direct incident radiation in a predetermined direction.

28. The catheter of claim 1 wherein the transmission output of the at least one delivery waveguide comprises scattering particles and a reflective terminating member so as to direct radiation in a direction that is transverse to a longitudinal axis of the at least one delivery waveguide.

29. The catheter of claim 1 wherein the balloon is sealed to the flexible conduit at a first longitudinal position and the second longitudinal position of the flexible conduit.

30. The catheter of claim 1 wherein the balloon is coupled to the conduit at a first longitudinal position of the conduit at a first portion of the balloon and wherein the balloon is coupled to the conduit at a second longitudinal position of the conduit at a second portion of the balloon, and wherein the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide are located within the balloon between the first and second longitudinal positions of the conduit.

31. The catheter of claim 1 further comprising a guidewire sheath coupled to the conduit at the distal end of the conduit, wherein the balloon is coupled to the guidewire sheath and conduit at a first portion of the balloon and wherein the balloon is coupled to the guidewire sheath at a second portion of the balloon.

32. The catheter of claim 1 wherein the flexible conduit comprises a core tube including a guidewire lumen.

33. The catheter of claim 32 wherein the at least one collection waveguide and the at least one delivery waveguide are positioned within a fluid transfer lumen of the core tube along a majority of its length.

34. The catheter of claim 32 wherein the at least one collection waveguide and the at least one delivery waveguide are positioned within a catheter sheath surrounding the core tube along a majority of its length.

35. The catheter of claim 1 wherein at least one of the at least one delivery waveguide and the at least one collection waveguide comprises graded-index optical fiber.

36. The catheter of claim 1 wherein at least one of the at least one delivery waveguide and the at least one collection waveguide has a numerical aperture between approximately 0.22 and 0.4.

37. The catheter of claim 1 wherein the at least one delivery waveguide comprises a fiber having a fiber core diameter of between about 9 and 100 microns.

38. The catheter of claim 1 wherein the at least one collection waveguide comprises a fiber having a fiber core diameter of between about 50 and 200 microns.

39. The catheter of claim 1 wherein the at least one delivery waveguide comprises a fiber having a fiber core diameter of about 50 microns and wherein the at least one collection waveguide comprises a fiber having a fiber core diameter of about 100 microns.

40. The catheter of claim 1 wherein a maximum outer diameter of the catheter including the flexible conduit, the at least one delivery waveguide, the at least one collection waveguide and the balloon is less than about 1.5 millimeters when the balloon is uninflated.

41. A system for probing and treating a body lumen comprising:

a flexible conduit that is elongated along a longitudinal axis suitable for insertion into a body lumen, the conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide integrated with the flexible conduit;

at least one radiation source connected to a transmission input of the at least one delivery waveguide, the radiation source constructed and arranged to provide radiation at a wavelength in a range of about 250 to 2500 nanometers;

at least one optical detector connected to a transmission output of the at least one collection waveguide; and

a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon.

42. The system of claim 41 wherein the transmission output of the at least one collection waveguide is connected to a spectrometer, the spectrometer constructed and arranged to scan radiation and perform spectroscopy at the wavelength in the range of about 250 nm to 2500 nm.

43. The system of claim 42 wherein the spectrometer is configured to perform spectroscopy selected from the group of spectroscopy methods consisting of fluorescence, light scatter, optical coherence reflectometry, optical coherence tomography, speckle correlometry, Raman, and diffuse reflectance spectroscopy.

44. The system of claim 42 wherein the spectrometer is constructed and arranged to scan radiation and perform spectroscopy at a wavelength within the range of about 750 nm to 2500 nm.

45. The system of claim 42 wherein the spectrometer is constructed and arranged to scan radiation and perform spectroscopy using one or more ranges of wavelengths.

46. The system of claim 45 wherein a scan using the one or more ranges of wavelengths includes a scan using one or more discrete wavelengths.

47. The system of claim 41 further comprising a controller that is programmed to automate control of activation and deactivation of the at least one radiation sources and the at least one optical detectors, to further control analysis of data collected by the system.

48. The system of claim 47 wherein the system is constructed and arranged for use in a medical care facility including a hospital or outpatient unit.

49. The system of claim 47 wherein the controller is programmed to operate a human-interactive interface that provides an operator with feedback about data and analysis of the spectroscopy, the interface providing information for real-time diagnosis.

50. The system of claim 47 wherein the controller is programmed to identify one or more characteristics of targeted tissue including at least one of:

presence of chemical components, tissue morphological structures, water content, blood content, temperature, pH, and color.

51. The system of claim 47 wherein the controller is further programmed to discriminate between tissue characteristics and non-relevant artifacts including elements of the catheter and other elements artificially introduced into the body lumen.

52. The system of claim 51 wherein the artificially introduced elements include at least one of stents and the coatings of stents.

53. The system of claim 41 further comprising a switch coupled between the at least one radiation source and the at least one delivery waveguide that selects between multiple radiation sources for application of radiation to the at least one delivery waveguide.

54. The system of claim 41 further comprising a switch coupled between the at least one radiation source and the at least one delivery waveguide that selectively applies the at least one radiation source to the at least one delivery waveguide.

55. The system of claim 41 further comprising a therapy delivery subsystem.

56. The system of claim 55 wherein the therapy delivery subsystem further comprises a tube associated with the flexible conduit through which at least one of treatment drugs and agents can be delivered.

57. The system of claim 41 wherein the one or more radiation sources are configured to produce an output power of the radiation of less than about 20 milliwatts at locations outside the balloon when inflated.

58. A catheter for placement within a body lumen, the catheter comprising:

a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit; and

a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon, wherein the maximum outer diameter of the catheter, including the flexible conduit, the at least one delivery waveguide, the at least one collection waveguide and the balloon is less than about 1.5 millimeters when the balloon is uninflated.

59. The catheter of claim 58 wherein the at least one delivery waveguide and the at least one collection waveguide are constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers

60. The catheter of claim 58 wherein at least one of the at least one delivery waveguide and the at least one collection waveguide comprises graded-index optical fiber.

61. The catheter of claim 58 wherein at least one of the at least one delivery waveguide and the at least one collection waveguide has a numerical aperture between approximately 0.22 and 0.4.

62. The catheter of claim 58 wherein the at least one delivery waveguide comprises a fiber having a fiber core diameter of between about 9 and 100 microns.

63. The catheter of claim 58 wherein the at least one collection waveguide comprises a fiber having a fiber core diameter of between about 50 and 200 microns.

64. The catheter of claim 58 wherein the at least one delivery waveguide comprises a fiber having a fiber core diameter of about 50 microns and wherein the at least one collection waveguide comprises a fiber having a fiber core diameter of about 100 microns.

65. A method for providing analysis and treatment of a body lumen, the method comprising:

inserting into a body lumen a catheter including a flexible conduit, a lumen-expanding balloon, at least one delivery waveguide and at least one collection waveguide, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide being located within the balloon;

maneuvering the conduit into a designated region of the body lumen designated for treatment or analysis;

expanding the balloon in the designated region of the body lumen;

executing spectroscopic analysis of the designated region of the body lumen using radiation at a wavelength in a range of about 250 to 2500 nanometers by radiating the designated region of the body lumen with the radiation that is supplied at the transmission output of the at least one delivery waveguide, the supplied radiation passing through the balloon where it is incident on the designated region of the body lumen, and wherein radiation is returned through the balloon to the transmission input of the at least one collection waveguide.

66. The method of claim 65 wherein expanding the balloon therapeutically expands the body lumen.

67. The method of claim 66 wherein expanding the balloon to therapeutically expand the body lumen dilates the body lumen in the designated region.

68. The method of claim 65 wherein executing spectroscopic analysis is performed while the balloon is expanded.

69. The method of claim 65 wherein the insertion and maneuvering of the conduit and the expansion of the balloon follow procedures in accordance with percutaneous transluminal angioplasty.

70. The method of claim 65 wherein the insertion and maneuvering of the conduit and the expansion of the balloon follow procedures in accordance with percutaneous coronary transluminal angioplasty.

71. The method of claim 65 wherein the balloon is expanded such that the flow of blood between the balloon and the surrounding lumen tissue is substantially stopped.

72. The method of claim 65 wherein the spectroscopic analysis includes the characterization of one or more pathophysiologic or morphologic factors of surrounding tissue within an endovascular region.

73. The method of claim 72 wherein the pathophysiologic or morphologic factors include characterizing the presence, volume, and positioning of plaque within the endovascular region.

74. The method of claim 73 wherein the pathophysiologic or morphologic factors further include characteristics of plaque including at least one of collagen content, lipid content, calcium content, inflammation, or the relative positioning of pathophysiologic conditions within the plaque.

75. The method of claim 65 further comprising providing a stent on the lumen-expanding balloon for delivery in the designated region at the time of expanding the balloon.

76. The method of claim 65 wherein executing spectroscopic analysis further comprises:

collecting analysis data based on the radiation that is returned through the at least one collection waveguide; and

discriminating between collected analysis data associated with targeted tissue in the designated region and analysis data associated with artifacts including at least one of the balloon, a balloon expansion media, a guidewire, a stent, and an artificial material placed on a stent.

77. The method of claim 76 wherein the analysis data associated with artificial materials placed on stents include data associated with polymers.

78. The method of claim 76 wherein the analysis data associated with artificial materials placed on stents include data associated with drugs.

79. The method of claim 65 further comprising determining an appropriate treatment for the designated region using the spectroscopic analysis.

80. The method of claim 79 wherein determining an appropriate treatment includes selecting a type of stent most appropriate for insertion.

81. The method of claim 80 wherein determining a type of stent most appropriate for insertion includes selecting a drug and dosage to be eluted from the stent.

82. The method of claim 65 wherein executing spectroscopic analysis is performed while the balloon is partially inflated.

83. The method of claim 82 wherein the spectroscopic analysis performed while the balloon is partially inflated is used to calculate the location of damaged tissue.

84. The method of claim 83 wherein the calculation of the location of damaged tissue is used to guide the position of the conduit in the lumen prior to full inflation of the balloon.

85. The method of claim 65 further comprising determining a level of expansion of the balloon using the spectroscopic analysis.

86. The method of claim 65 wherein the spectroscopic analysis is executed on a 360 degree portion of a wall of the lumen.

87. The method of claim 65 wherein the executing spectroscopic analysis includes selectively switching delivery of radiation between separate ones of the at least one delivery waveguides.

88. The method of claim 87 wherein the selective switching distributes radiation to radiate predefined quadrants about the circumference of the balloon.

89. The method of claim 87 wherein the selective switching comprises selective operation of multiple radiation sources.

90. The method of claim 65 wherein executing spectroscopic analysis includes selectively scanning across one or more ranges of wavelengths.

91. The method of claim 90 wherein executing spectroscopic analysis includes scanning using one or more ranges of wavelengths between about 750 nm and 2500 nm.

92. The method of claim 90 wherein the one or more ranges of wavelengths are selected from ranges of approximately 250-930 nanometers, 1100-1385 nanometers, 1600-1850 nanometers, and 2100-2500 nanometers.

93. The method of claim 90 wherein selectively scanning across one or more ranges of wavelengths includes scanning using one or more discrete wavelengths.

94. The method of claim 65 wherein expanding the balloon comprises expanding the balloon with a biocompatible liquid that substantially minimizes the effects of scattering, distortion, and deflection of the radiation.

95. The method of claim 94 wherein the biocompatible liquid is at least one selected from the group consisting of:

carbon dioxide, saline, deuterium oxide, and glycerin.

96. The method of claim 95 wherein the biocompatible liquid comprises super-saturated saline solution.

97. The method of claim 65 wherein executing spectroscopic analysis further comprises collecting analysis data based on the radiation that is received through the at least one collection waveguide.

98. The method of claim 97 wherein collecting analysis data occurs within a time period of less than about 1 second.

99. The method of claim 98 further comprising analyzing the collected analysis data.

100. The method of claim 65 wherein an amount of power emitted from the lumen-expanding balloon during the spectroscopic analysis is less than about 20 milliwatts.

101. A method of forming a catheter for placement within a body lumen comprising:

providing a flexible conduit that is elongated along a longitudinal axis suitable for insertion into a body lumen, the flexible conduit having a proximal end and a distal end;

providing at least one delivery waveguide and at least one collection waveguide along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers; and

providing a lumen-expanding inflatable balloon about a portion of the conduit so that a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide are located within the balloon.

102. The method of claim 101 further comprising forming distal portions of the at least one delivery waveguide and the at least one collection waveguide in a helical arrangement by:

stripping end portions of the waveguides of outer jacketing;

securing unstripped portions of the waveguides;

applying a heat source to the end portions of the waveguides to be helically arranged, the heat source sufficient to make malleable the end portions; and

applying forces to rotate the waveguides about a core segment and to translate longitudinally the end portions of the waveguides in the direction of their secured unstripped portions.

103. The method of claim 102 wherein the waveguides are helically arranged at predetermined angles by applying in a predetermined manner the forces to rotate and translate longitudinally the ends of the waveguides.

104. The method of claim 102 wherein securing the unstripped portions of the waveguides is performed using at least one locking member disposed about the core segment and the forces for rotating and translating are applied with a rotatably and translatably movable member disposed about the core segment.

105. The method of claim 104 wherein the end portions of the waveguides are translated a distance ranging from about 2 microns to 2 millimeters, while the end portions of the waveguides are rotated about 30 to 360 degrees about the core segment.

106. The method of claim 102 wherein the heat source provides heat at about 1600 Celsius.

107. The method of claim 101 wherein the balloon is laser welded to the conduit.

108. The method of claim 101 further comprising providing a waveguide holder for contiguously retaining the at least one delivery waveguide and at least one collection waveguide to the flexible conduit.

109. The method of claim 108 wherein the at least one delivery waveguide and at least one collection waveguide are assembled with said waveguide holder prior to providing said at least one delivery waveguide and the at least one collection waveguide along the flexible conduit.

110. The method of claim 109 further comprising shaping the transmission output of said at least one delivery waveguide after the assembly with said waveguide holder.

111. The method of claim 109 further comprising shaping the transmission input of said at least one collection waveguide after the assembly with said waveguide holder.

112. The method of claim 108 wherein the waveguide holder for holding the at least one delivery waveguide and at least one collection waveguide comprises a holder body having a plurality of holes.

113. The method of claim 112 further comprising aligning and fixing the plurality of holes with the longitudinal axis of the flexible conduit.

114. The method of claim 112 further comprising correspondingly aligning and fixing the plurality of holes with one or more reflective surfaces.

115. The method of claim 114 wherein said one or more reflective surfaces are disposed radially about the flexible conduit as part of a multi-faceted reflecting element.

116. The method of claim 114 wherein said one or more reflective surfaces comprises a cone-shaped reflecting element aligned with the longitudinal axis of the flexible conduit.

117. The method of claim 108 wherein the waveguide holder for holding the at least one delivery waveguide and at least one collection waveguide comprises a holder body having a plurality of grooves disposed radially about the flexible conduit.

118. A catheter for placement within a body lumen, the catheter comprising:

a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers; and

a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide being positioned along an outer surface of the balloon.

119. The catheter of claim 118 further comprising a ring that couples body portions of the at least one delivery waveguide and the at least one collection waveguide to the flexible conduit.

120. The catheter of claim 118 wherein the transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide are mounted on the outer surface of the balloon.

121. A catheter for placement within a body lumen, the catheter comprising:

a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers; and

a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide being mounted to an inner surface of the balloon.

122. The catheter of claim 121 further comprising a ring that couples body portions of the at least one delivery waveguide and the at least one collection waveguide to the flexible conduit.