Biochip with microchannels
First Claim
1. A biochip with a plurality of microchannels, comprising:
- a substrate having a top surface and a bottom surface and having a plurality of microchannels formed on the top surface of the substrate and parallel to each other arranged; and
a lid covering the top surface of the substrate, wherein each microchannel has an inlet and an outlet at both ends of the microchannel, the inlet and the outlet are respectively connected to a splitting pool and a collection pool on the top surface of the substrate, and a fluid is able to flow into the splitting pool via an inflow mouth, pass through the microchannels, flow into the collection pool and flow out from an outflow mouth, wherein the microchannels are deeper at the inlet and shallower at the outlet and accordingly have a positive slope.
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Accused Products
Abstract
A biochip with multiple microchannels is provided. Due to the sloped microchannels, the fluids in the microchannels flow at substantially the same rate, thus facilitating cellular experiments of potential medicaments. Since the flow resistance of the sloped microchannels changes gradually, the fluids can flow in the microchannels without retention and the reagents react consistently with the cells in the microchannels. Hence, the cellular reaction time for the reagents in the microchannels can be correctly determined. Moreover, the biochip of this invention further includes at least one multi-splitter to control the influx or efflux of the fluids.
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Citations
22 Claims
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1. A biochip with a plurality of microchannels, comprising:
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a substrate having a top surface and a bottom surface and having a plurality of microchannels formed on the top surface of the substrate and parallel to each other arranged; and
a lid covering the top surface of the substrate, wherein each microchannel has an inlet and an outlet at both ends of the microchannel, the inlet and the outlet are respectively connected to a splitting pool and a collection pool on the top surface of the substrate, and a fluid is able to flow into the splitting pool via an inflow mouth, pass through the microchannels, flow into the collection pool and flow out from an outflow mouth, wherein the microchannels are deeper at the inlet and shallower at the outlet and accordingly have a positive slope. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A biochip, comprising:
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a substrate having a top surface and a bottom surface and having a plurality of microchannels formed on the top surface of the substrate, wherein the microchannels are arranged in parallel; and
a lid covering the top surface of the substrate, wherein each microchannel has an inlet and an outlet at both ends of the microchannel, the inlet and the outlet are respectively connected to a splitting pool and a collection pool on the top surface of the substrate, and a fluid is able to flow into the splitting pool via an inflow mouth, pass through the microchannels, flow into the collection pool and flow out from an outflow mouth, wherein the splitting pool comprises a multi-splitter with a plurality of channels in different depths for evenly dividing the fluid to flow into the microchannels. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification