Coated vaso-occlusion device

• US 20070082021A1
• Filed: 09/28/2006
• Published: 04/12/2007
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Bates, Brian
• Application Number:
  US11/529,872
• Publication Number:
  US 20070082021A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/3954 magnetic, e.g. NMR or MRI
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.

Claims

1. A vaso-occlusion device comprising:

at least one occluding element comprising at least one polymeric material, the at least one polymeric material having a plurality of holes at least partially filled with at least one bioactive agent;

where the at least one bioactive agent promotes occlusion of a vessel in a subject and where the vaso-occlusion device is configured to occlude a vessel in the subject.

2. The vaso-occlusion device of claim 1, where at least a surface of the at least one occluding element is coated with the at least one polymeric material.

3. The vaso-occlusion device of claim 1, where at least a portion of the at least one occluding element is made from the at least one polymeric material

4. The vaso-occlusion device of claim 1, where the at least one occluding element is substantially made from the at least one polymeric material.

5. The vaso-occlusion device of claim 1, where at least one bioactive agent is a thrombogenic, fibrogenic, antithrombolytic or antifibrinolytic agent.

6. The vaso-occlusion device of claim 5, where at least one bioactive agent is selected from the group consisting of plasmin, thrombin, prothrombin, fibrinogen, Factor V, Factor Va, Factor VII, Factor VIIa, Factor VIII, Factor VIIIa, Factor IX, Factor IXa, Factor X, Factor Xa, Factor XI, Factor XIa, Factor XII, XIIa, Factor XIII, vWF, aminocaproic acid, aprotinin, tranexamic acid, desopressin, etamsylate, integrin, peptide containing arginine-glycine-aspartic acid residues, collagen, elastin, fibronectin, laminin, vitronectin;

homocysteine, CTGF, VEGF, PDGF, FGF, KGF, TNF, EGF, TGF-α

, TGF-β

, IL-1, IL-2, IL-6, and IL-8.

7. The vaso-occlusion device of claim 1, further comprising a resorbable agent.

8. The vaso-occlusion device of claim 1, where the at least one occluding element is a space-filling structural element having a three-dimensional structure configured for occluding a vessel.

9. The vaso-occlusion device of claim 8, where the at least one space-filling structural element is a coil, thread, or fiber, or combination thereof.

10. The vaso-occlusion device of claim 1, where the at least one occluding element is an expandable occlusion bag, the occlusion bag enclosing one or more space-filling structural elements.

11. The vaso-occlusion device of claim 1, where the at least one occluding element is an expandable occlusion bag, the occlusion bag enclosing at least one space-filling material.

12. The vaso-occlusion device of claim 1, where the at least one polymeric material comprises a polymer selected from the group consisting of polyesters, fluorinated polymers, polysiloxanes, polyurethanes, polyolefins, polyacrylonitrile, nylons, polyaramids and polysulfones.

13. The vaso-occlusion device of claim 1, where the at least one polymeric material comprises a polyetherurethane urea and a surface modifying agent comprising a siloxane.

14. The vaso-occlusion device of claim 17, where the at least one polymeric material comprises THORALON.

15. The vaso-occlusion device of claim 1, where the at least one polymeric material comprises a textile having a plurality of fibers, wherein the textile is selected from the group consisting of woven, non-woven, and knitted textiles.

16. The vaso-occlusion device of claim 15, where at least one of the plurality of fibers contains a plurality of holes, where at least some of the plurality of holes are at least partially filled with at least one bioactive agent.

17. The vaso-occlusion device of claim 15, where the textile comprises a synthetic polymer.

18. The vaso-occlusion device of claim 17, where the synthetic polymer is polyethylene terephthalate.

19. The vaso-occlusion device of claim 1, where at least a surface of the occluding element comprises a thrombogenic fibrous material selected from the group consisting of DACRON, cotton, silk, wool, polyester, and combinations thereof.

20. A method of occluding a vessel in a patient comprising:

a. providing a vaso-occlusion device comprising;

at least one occluding element comprising at least one polymeric material, the at least one polymeric material having a plurality of holes at least partially filled with at least one bioactive agent;

where the at least one bioactive agent promotes occlusion of a vessel in a subject and where the vaso-occlusion device is configured to occlude a vessel in the subject; and

b. positioning the vaso-occlusion device in a vessel site of the patient so that the device occludes the vessel.