Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
First Claim
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1. A method for preventing or treating a bone disorder comprising:
- (a) generating a plurality of micro-channels in an area of the skin of a subject;
(b) affixing a patch to the area of the skin of the subject, the patch comprising a dried pharmaceutical composition comprising a therapeutically effective amount of a parathyroid hormone (PTH) peptide or a fragment or derivative thereof, thereby preventing or treating the bone disorder or disease.
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Abstract
The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of a peptide or polypeptide that generates hydrophilic micro-channels, and a patch comprising dried therapeutically peptide or polypeptide. Particularly, the system of the present invention facilitates transdermal delivery of parathyroid hormone useful for preventing or treating bone disorders.
53 Citations
17 Claims
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1. A method for preventing or treating a bone disorder comprising:
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(a) generating a plurality of micro-channels in an area of the skin of a subject;
(b) affixing a patch to the area of the skin of the subject, the patch comprising a dried pharmaceutical composition comprising a therapeutically effective amount of a parathyroid hormone (PTH) peptide or a fragment or derivative thereof, thereby preventing or treating the bone disorder or disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification