Implantable pump for protein delivery for obesity control by drug infusion into the brain
First Claim
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1. A method of suppressing appetite comprising:
- implanting a drug infusion pump into a site in a subject; and
delivering a stable suspension of an effective dosage of an appetite suppressing agent to a site in a central nervous system of the subject, wherein the appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
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Abstract
Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
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Citations
21 Claims
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1. A method of suppressing appetite comprising:
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implanting a drug infusion pump into a site in a subject; and
delivering a stable suspension of an effective dosage of an appetite suppressing agent to a site in a central nervous system of the subject, wherein the appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for ameliorating obesity in a subject, comprising:
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implanting a drug infusion pump into a site in a subject; and
delivering a stable suspension of a melanocortin to a region in a central nervous system of the subject, wherein the melanocortin binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the melanocortin receptor function to suppress appetite, thereby ameliorating obesity. - View Dependent Claims (11, 14, 15, 16, 17)
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12. The method of claim I 1, wherein the alpha melanocyte-stimulating hormone (α
- -MSH) peptide is conjugated to an antibody or antibody fragment.
- View Dependent Claims (13)
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18. A system for suppressing appetite comprising:
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an implantable drug infusion pump; and
a stable suspension of an effective dosage of an appetite suppressing agent wherein the appetite suppressing agent can bind to a target receptor on a neural cell in the central nervous system and upon binding modifies the receptor function to suppress appetite. - View Dependent Claims (19, 20, 21)
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Specification