IONTOPHORETIC DEVICE AND METHOD OF DELIVERY OF ACTIVE AGENTS TO BIOLOGICAL INTERFACE
First Claim
1. An iontophoresis device to delivery active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
- an active electrode element operable to provide an electrical potential;
an electrolyte reservoir comprising an electrolyte composition; and
an inner active agent reservoir including a gel matrix and distributed in said gel matrix, a first positively charged active agent, the gel matrix comprising a hydrophilic polycarboxylated polymer having net negative charges.
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Accused Products
Abstract
An iontophoresis device includes an active electrode element operable to provide an electrical potential; an electrolyte reservoir comprising an electrolyte composition; an inner active agent reservoir comprising a gel matrix and distributed in said gel matrix, a first positively charged active agent; an inner ion selective membrane deposed between said electrolyte reservoir and said inner active agent reservoir; and an outermost ion selective membrane having an outer surface, the outer surface being against the biological interface, wherein, the gel matrix comprises a hydrophilic polycarboxylated polymer having net negative charges.
153 Citations
37 Claims
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1. An iontophoresis device to delivery active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
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an active electrode element operable to provide an electrical potential;
an electrolyte reservoir comprising an electrolyte composition; and
an inner active agent reservoir including a gel matrix and distributed in said gel matrix, a first positively charged active agent, the gel matrix comprising a hydrophilic polycarboxylated polymer having net negative charges. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. An article of manufacture for transdermal administration of medication by iontophoresis, comprising:
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an active electrode assembly including an active electrode element operable to provide an electrical potential;
an electrolyte reservoir comprising an electrolyte composition; and
an inner active agent reservoir including a gel matrix, the gel matrix being a hydrophilic polycarboxylated polymer having net negative charges; and
at least one dosage form comprising one or more active agents loaded in the inner active agent reservoir. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for transdermal administration of an active agent by iontophoresis, comprising:
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positioning an active electrode assembly and a counter electrode assembly of an iontophoresis device on a biological interface of a subject, the active electrode assembly including an active electrode element operable to provide an electrical potential;
an electrolyte reservoir comprising an electrolyte composition; and
an inner active agent reservoir comprising a gel matrix and distributed in said gel matrix, a positively charged active agent, the gel matrix comprising a hydrophilic polycarboxylated polymer having net negative charges;
wherein the positively charged active agent is bound to the gel matrix; and
applying a sufficient amount of current to release the active agent from the gel matrix and transport the active agent to the biological interface of the subject, and to administer a therapeutically effective amount of the positively charged active agent in the subject for a limited period of time. - View Dependent Claims (36, 37)
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Specification