Devices and methods for facilitating controlled bone growth or repair

• US 20070083265A1
• Filed: 09/27/2006
• Published: 04/12/2007
• Est. Priority Date: 12/14/2000
• Status: Active Grant

• Current Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Inventors: Malone, David
• Granted Patent: US 8,142,503 B2
• Time in Patent Office: Days
• US Class Current: 623/17.110
• CPC Class Codes: A61B 17/7064 Devices acting on, attached to, or simulating the effect of, vertebral facets; Tools therefor
• CPC Class Codes: A61B 17/72 Intramedullary pins, nails or other devices A61B17/744 takes precedence
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/8685 comprising multiple separate parts
• CPC Class Codes: A61F 2/30744 End caps, e.g. for closing an endoprosthetic cavity
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2/446 having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
• CPC Class Codes: A61F 2/4611 of spinal prostheses
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30115 circular-O-shaped
• CPC Class Codes: A61F 2002/30143 hexagonal
• CPC Class Codes: A61F 2002/30153 rectangular
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30364 Rotation about the common longitudinal axis
• CPC Class Codes: A61F 2002/30593 hollow
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30616 : Sets comprising a plurality of prosthetic parts of different sizes or orientations
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30787 : inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/3085 : with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
• CPC Class Codes: A61F 2002/30904 : serrated profile, i.e. saw-toothed
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/3611 : Heads or epiphyseal parts of femur
• CPC Class Codes: A61F 2002/368 : with lateral apertures, bores, holes or openings, e.g. for reducing the mass, for receiving fixation screws or for communicating with the inside of a hollow shaft
• CPC Class Codes: A61F 2002/448 : comprising multiple adjacent spinal implants within the same intervertebral space or within the same vertebra, e.g. comprising two adjacent spinal implants
• CPC Class Codes: A61F 2220/0033 : made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2230/0006 : circular
• CPC Class Codes: A61F 2230/0017 : Angular shapes
• CPC Class Codes: A61F 2230/0019 : rectangular
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Abstract

Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substance is delivered onto carrier material through a port. A pathway delivers substance from the carrier receiving area to the bone surface. The body may be in the form of a spinal fusion cage, facet fusion screw, artificial joint, bone fixation plate, interbody graft, IM nail, hip stem, or other bone-to-bone appliances or bone-to-device appliances. In use, carrier is installed in the carrier receiving area of the device. The device is then implanted adjacent a bone. The substance is applied to the carrier for subsequent delivery to the bone. By doping carrier material after device implantation, inadvertent contact of the substance with non-target bone is more easily eliminated.

Claims

1. A bone implantable device for locating adjacent a target bone structure, said bone implantable device comprising:

a body defining an outside surface;

a carrier receiving area defined by said body;

an un-doped carrier material loaded in said carrier receiving area;

a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure.

2. The bone implantable device according to claim 1 wherein:

said body comprises a threaded fusion member or facet screw passing through a superior facet of a lower vertebrae from a location adjacent a superior process of said lower vertebrae and through an inferior facet of said upper vertebrae for fusing said facet joint.

3. The bone implantable device according to claim 1 wherein:

said body comprises a threaded fusion member or facet screw passing through a superior facet of a lower vertebrae from a location adjacent a superior process of a lower vertebrae and through an inferior facet of an upper vertebrae and said spinous process of said upper vertebrae for fusing said facet joint.

4. The bone implantable device according to claim 1 wherein:

Said body comprises a threaded fusion member or facet screw passing through said inferior facet of said upper vertebrae from a location adjacent said spinous process of said upper vertebrae and through superior facet of said lower vertebrae for fusing said facet joint.

5. The bone implantable device according to claim 1 wherein:

Said body comprises a wedge member located in said fusion joint;

a threaded fusion member or facet screw passing through said superior facet of said lower vertebrae from a location adjacent said superior process of said lower vertebrae, through said wedge member, and through said inferior facet of said upper vertebrae for fusing said facet joint.

6. The bone implantable device according to claim 1 wherein:

Said body comprises a wedge member located in said fusion joint;

a threaded fusion member or facet screw passing through said superior facet of said lower vertebrae from a location adjacent said superior process of said lower vertebrae and through said inferior facet of said upper vertebrae and said spinous process of said upper vertebrae for fusing said facet joint.

7. The bone implantable device according to claim 1 wherein:

Said body comprises a wedge member located in said fusion joint.

8. The bone implantable device according to claim 1 wherein:

Said body comprises a wedge member having a narrow end and a wide end and an upper surface and a lower surface, said wedge member having a plurality of ridges for facilitating one way insertion into a facet joint, said wedge having an internal cavity for receiving a substance such as bone morphogenic protein, and a port for injecting material into said cavity, a plurality of orifices on said upper and lower surface for facilitating migration of said substance out of said cavity.

9. The bone implantable device according to claim 1 wherein:

Said body comprises an artificial facet member affixed to the vertebral body of said lower vertebrae at a location of a removed superior facet;

a threaded fusion member or facet screw passing through said artificial facet member from a location adjacent said superior process of said lower vertebrae and through said inferior facet of said upper vertebrae and said spinous process of said upper vertebrae for fusing said facet joint.

10. The bone implantable device according to claim 1 wherein:

Said body comprises an artificial facet member affixed to the vertebral body of said lower vertebrae at a location of a removed superior facet;

a threaded fusion member or facet screw passing through a distal end of said artificial facet member for securing said artificial facet member to said vertebral body of said lower vertebral.

11. The bone implantable device according to claim 1 wherein:

Said body comprises at least one threaded fusion member or facet screw located in the facet joint between the superior facet of said lower vertebrae and said inferior facet of said upper vertebrae for fusing said facet joint;