Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
First Claim
1. A formulation comprising insulin selected from the group consisting of intermediate acting, and long acting insulin with an effective amount of a chelator and an acidifying agent to enhance the rate or amount of uptake by a patient.
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Accused Products
Abstract
It has been discovered that by combining a chelator, such as ethylenediaminetetraacetic acid, with an acidifier, such as citric acid, the insulin is absorbed much more rapidly than in the absence of the chelator and acidifier, with a commercially available rapid, intermediate or long lasting insulin such as glargine, one can increase and/or prolong the bioavailability of the insulin mixture. The formulations are suitable for administration by injection or to a mucosal surface such as the pulmonary or oral regions, although subcutaneous injection is preferred.
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Citations
16 Claims
- 1. A formulation comprising insulin selected from the group consisting of intermediate acting, and long acting insulin with an effective amount of a chelator and an acidifying agent to enhance the rate or amount of uptake by a patient.
- 11. A. formulation suitable for pulmonary administration of an insulin in combination with an effective amount of a chelator and an acidifying agent to enhance the rate or amount of uptake by a patient.
Specification