Formation of medically useful gels comprising microporous particles and methods of use

• US 20070086958A1
• Filed: 10/13/2006
• Published: 04/19/2007
• Est. Priority Date: 10/14/2005
• Status: Abandoned Application

• Current Assignee: Medafor Incorporated (Becton, Dickinson & Co)
• Original Assignee: Medafor Incorporated (Becton, Dickinson & Co)
• Inventors: Drake, James, Gronda, Ann
• Application Number:
  US11/580,372
• Publication Number:
  US 20070086958A1
• Time in Patent Office: Days
• US Class Current: 424/46
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/7015 Drug-containing film-forming compositions, e.g. spray-on
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

Compositions and methods use the gel-forming properties of microporous particles to create useful formulations combining two free-flowing materials to produce a hydrogel mass. The free-flowing materials preferably provide dry microporous particles (preferably as an aerosol) that may contain additional agents, and a second composition of a fluid material which is an aqueous solution of one or more high molecular weight polymers capable of forming a hydrogel upon further concentration and/or reaction. The hydrogels can be preferably formed on a surface by spraying the two compositions as fluids together in the proper ratio onto the surface.

Claims

1. A method of treating a surface of tissue of a patient comprising applying to the surface of tissue at least one liquid composition so that both a) a gel-forming composition comprising a solution, suspension, dispersion or emulsion and b) porous microparticles are applied to the surface.

2. The method of claim 1 wherein the gel-forming composition is a hydrogel-forming composition and a hydrogel is applied as a first liquid composition and the porous microparticles are applied as a second composition.

3. The method of claim 2 wherein the porous microparticles are applied as a dry composition.

4. The method of claim 2 wherein at least one of the first composition and the second composition are applied by spraying.

5. The method of claim 1 wherein the gel-forming composition comprises at least one ingredient selected from the group consisting of a) thrombin, b) albumin-fibrinogen, c) hyaluronan, d) cellulosic polymer, e) acrylic polymer and f) hydrophilic and crosslinkable polymer, and both the first composition and the second composition are applied by spraying.

6. The method of claim 3 wherein at least one of the first composition and the second composition are applied by spraying.

7. The method of claim 4 wherein both the first composition and the second composition are applied by spraying.

8. The method of claim 2 wherein the first composition is applied at the same time as or before application of the second composition.

9. The method of claim 2 wherein the second composition is applied before application of the first composition.

11. The system of claim 1 wherein both the gel or hydrogel composition is provided as a liquid and the porous microparticles are provided as a dry composition from their respective sources.

12. The system of claim 11 wherein the first applicator system comprises a spray system.

13. The system of claim 12 wherein the second applicator system comprises a spray system.

16. The method of claim 1 wherein the microporous particles have pore sizes for molecular weight cutoff of molecules during use as a sieve at an intervals between 5,000 Daltons and 200,000 Daltons.

17. The method of claim 16 wherein the microporous particles have an effective pore volume of 2% to 75% of the total volume of the microporous particles.

18. The method of claim 1 wherein the microporous particles are combined with a crosslinking agent for the gel-forming composition prior to contact with the gel-forming composition.

19. The method of claim 18 wherein contacting of the gel-forming composition and the microporous particles with crosslinking agent occurs on the surface of tissue to be treated.

10. An applicator system for application of treatment of compositions to tissue surfaces of patients comprising a first source of a gel or hydrogel composition as a solution, dispersion, suspension or emulsion and a second source of porous microparticles, a first conveying system for conveying said first composition and a second conveying system for conveying the second composition, and a first applicator system for applying the first composition to a surface and a second applicator system for applying the second composition to a surface.

14. Tissue of a patient having a barrier layer adhered to a surface of the tissue comprising a gelled product of an aqueous solution, aqueous suspension, aqueous dispersion or aqueous emulsion and microporous particles.

15. Tissue of a patient having a layer applied to a surface of the tissue comprising a gelled product of an aqueous solution/suspension/dispersion and microporous particles to facilitate healing.