Multi-Component Pharmaceutical Dosage Form
7 Assignments
0 Petitions
Accused Products
Abstract
A multi-component pharmaceutical dosage form comprising a plurality of drug substance—containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
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Citations
59 Claims
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1-37. -37. (canceled)
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38. A multi-component pharmaceutical dosage form which comprises a plurality of sub-units, each sub-unit being selected from:
- a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the solid matrix, in which said dosage form comprises at least two drug substance-containing sub-units, in which the plurality of sub-units are disposed in end-to-end relationship along a line, and have outer walls surrounding said line, in which each of said plurality of sub-units is joined to at least one other sub-unit by a joint comprising a plug constituting a unitary part of one of the joined sub-units and a socket formed as a unitary part of the other of the joined sub-units, wherein engaging parts of the outer walls of the respective joined sub-units delimit the relative positions of the respective plug and socket along said line.
- View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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55. A multi-component pharmaceutical dosage form which comprises a plurality of sub-units, each sub-unit being selected from:
- a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the solid matrix, in which said dosage form comprises at least two drug substance-containing sub-units, in which the plurality of sub-units are disposed in end-to-end relationship along a line, and have outer walls surrounding said line, in which each of said plurality of sub-units is joined to at least one other sub-unit by a joint comprising a plug constituting a unitary part of one of the joined sub-units and a socket formed as a unitary part of the other of the joined sub-units, wherein the two drug substance-containing sub-units are capsule compartment sub-units, wherein at least the outer walls of said two drug substance-containing capsule compartment sub-units are formed of polymers, the polymers being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment, and
wherein the release characteristics of the outer polymer walls of said two capsule compartment sub-units are different. - View Dependent Claims (56, 57, 58, 59)
- a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the solid matrix, in which said dosage form comprises at least two drug substance-containing sub-units, in which the plurality of sub-units are disposed in end-to-end relationship along a line, and have outer walls surrounding said line, in which each of said plurality of sub-units is joined to at least one other sub-unit by a joint comprising a plug constituting a unitary part of one of the joined sub-units and a socket formed as a unitary part of the other of the joined sub-units, wherein the two drug substance-containing sub-units are capsule compartment sub-units, wherein at least the outer walls of said two drug substance-containing capsule compartment sub-units are formed of polymers, the polymers being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment, and
Specification