Ultrasound coupling medium for use in medical diagnostics

• US 20070087060A1
• Filed: 05/21/2004
• Published: 04/19/2007
• Est. Priority Date: 05/21/2003
• Status: Abandoned Application

• Current Assignee: Joker AG
• Original Assignee: Joker AG
• Inventors: Dietrich, Rene, Kreusch, Manfred
• Application Number:
  US10/557,913
• Publication Number:
  US 20070087060A1
• Time in Patent Office: Days
• US Class Current: 424/486
• CPC Class Codes: A61K 49/226 Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Abstract

A composition of an ultrasound coupling medium is provided. The composition comprises at least 90% water, at least one preservative, and at least one base substance, wherein the composition is extensible into a film with a thickness of up to 1/10 mm, wherein the composition can withstand a pressure of up to 30 kp without tearing, wherein the composition can adapt exactly to skin surface without causing any significant air pockets, and wherein the composition can be removed from skin with substantially no residue left behind. The at least one base substance may be a galactomannan, a polyvinyl alcohol (PVA), a complex formation of galactomannan and borate ions, or comninations thereof.

Claims

1-19. -19. (canceled)

20. A composition of an ultrasound coupling medium, comprising:

(a) at least 90% water;

(b) at least one preservative; and

(c) at least one base substance,

wherein the composition is extensible into a film with a thickness of up to 1/10 mm, wherein the composition can withstand a pressure of up to 30 kp without tearing, wherein the composition can adapt exactly to skin surface without causing any significant air pockets, and wherein the composition can be removed from skin with substantially no residue left behind.

21. The composition of claim 20, wherein the at least one base substance is selected from the group consisting of:

galactomannan, polyvinyl alcohol (PVA), a complex formation of galactomannan and borate ions, and combinations thereof.

22. The composition of claim 20, wherein the at least one base substance is a galactomannan and boron complex having a galactomannan concentration of 1-5% by weight, and is free of polyvinyl alcohol.

23. The composition of claim 20, wherein the at least one base substance is a galactomannan and boron complex having a galactomannan concentration of 3-4% by weight, and is free of polyvinyl alcohol.

24. The composition of claim 20, wherein the composition comprises 1 to 5 percent by weight of galactomannan, 0.3 to 5 percent by weight of polyvinyl alcohol, and 0.1 to 0.5 percent by weight of sodium tetraborate.

25. The composition of claim 24, wherein the composition has a pH value between 6.5 and 8.5.

26. The composition of claim 20, wherein the composition further comprises a softener selected from the group consisting of:

ethyl glycol, di-ethylene glycol, tri-ethylene glycol, PEG, and glycerol.

27. The composition of claim 26, wherein the softener is 0.2 to 1.5% by weight of glycerol.

28. The composition of claim 20, wherein the gel point of the composition lies in a range from 20 mHz to 5 Hz.

29. The composition of claim 20, wherein the gel point of the composition lies in a range from 100 mHz and 1 Hz.

30. The composition of claim 20, wherein the at least one preservative is selected from the group consisting of pHB-methylester, pHB-propylester, salt of pHB-methyleste, salt of pHB-propylester, and mixtures thereof.

31. The composition of claim 20, wherein the composition further comprises colorings, selected from the group consisting of:

Brilliant blue FCF (E133, C.I. No.

     42090) and Patent blue V (E131 C.I. No.

     42051).

32. The composition of claim 21, wherein the polyvinyl alcohol has a hydrolysis degree of at least 85 mole %.

33. The composition of claim 32, wherein the composition comprises a 4% aqueous PVA-solution with a viscosity of 30 mPa·

s. (20°

C.) and a 2% aqueous hydroxypropyl guar solution with a viscosity of 10,000 to 12,000 mPa·

s. (20°

C.).

34. The composition of claim 21, wherein the polyvinyl alcohol has a hydrolysis degree of at least 98 mole %.

35. The composition of claim 21, wherein the galactomannan is an alkylated galactomannan with a substitution degree DS of 0.2 to 0.6.

36. The composition of claim 21, wherein the galactomannan is an alkylated galactomannan with a substitution degree DS of 0.3 to 0.5.

37. A method for medical dialogistic by applying an ultrasound coupling medium, comprising:

(a) at least 90% water;

(b) at least one preservative; and

(c) at least one base substance selected from the group consisting of;

galactomannan, polyvinyl alcohol (PVA), a complex formation of galactomannan and borate ions, and combinations thereof;

wherein the composition is extensible into a film with a thickness of up to 1/10 mm, wherein the composition can withstand a pressure of up to 30 kp without tearing, wherein the composition can adapt exactly to skin surface without causing any significant air pockets, and wherein the composition can be removed from skin with substantially no residue left behind.

38. A packaging of an ultrasound coupling medium comprising a composition and a cutting means for cutting off a gel strand, wherein the composition comprises at least 90% water, at least one preservative, at least one base substance selected from the group consisting of:

galactomannan, polyvinyl alcohol (PVA), a complex formation of galactomannan and borate ions, and combinations thereof, wherein the packaging is provided with a reclosable dispensing opening, wherein the cutting means is arranged in the region of the dispensing opening, and wherein the cutting means is a flat and pliable plastic strip provided with a front edge formed into a cutter.

39. The packaging of claim 38, wherein the plastic strip has a rectangular configuration, wherein the plastic strip is wider than the dispensing opening, and wherein the plastic strip is long enough in order to lead the cutter edge past the dispensing opening.