Surface-modified medical devices and method of making
First Claim
Patent Images
1. A medical device comprising a coating polymer that is attached to a surface thereof, the coating polymer providing a plurality of charges at a physiological condition.
1 Assignment
0 Petitions
Accused Products
Abstract
A medical device having a reduced affinity for bacterial attachment comprises a coating polymer that is attached to a surface thereof, the coating polymer providing a plurality of charges at a physiological condition. The medical device is produced by contacting the coating polymer with the medical device such that the coating polymer is attached thereto. The coating polymer may be attached to the medical device through an intermediate polymer.
43 Citations
30 Claims
- 1. A medical device comprising a coating polymer that is attached to a surface thereof, the coating polymer providing a plurality of charges at a physiological condition.
-
17. A medical device comprising a coating polymer that is attached to a surface thereof through an intermediate polymer, the coating polymer providing a plurality of charges at a physiological condition and comprising a poly(carboxylic acid) and poly(alkylene oxide) units;
- wherein the intermediate polymer comprises poly(DMA-co-GMA), and the poly(carboxylic acid) is selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), combinations thereof, and copolymers thereof.
- View Dependent Claims (18)
-
19. A method for reducing bacterial attachment to a medical device, the method comprising:
-
(a) providing the medical device having a plurality of medical-device surface functional groups;
(b) providing a first polymer having a plurality of at least first-polymer functional groups capable of interacting with the medical-device surface functional groups and with at least second-polymer functional groups of a second polymer;
(c) providing the second polymer having said at least second-polymer functional groups and a plurality of moieties that support a charge or are capable of becoming charged at a physiological condition; and
(d) contacting the medical device with the first and second polymers at a condition sufficient to produce the medical device having reduced affinity for bacterial attachment. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
-
-
27. A method for making a medical device, the method comprising:
-
(a) forming the medical device comprising a polymeric material having a plurality of medical-device surface functional groups;
(b) providing a first polymer having a plurality of at least first-polymer functional groups capable of interacting with the medical-device surface functional groups and with at least second-polymer functional groups of a second polymer;
(c) providing the second polymer having said at least second-polymer functional groups and a plurality of moieties that support a charge or are capable of becoming charged at a physiological condition; and
(d) contacting the medical device with the first and second polymers at a condition sufficient to produce the medical device having reduced affinity for bacterial attachment. - View Dependent Claims (28, 29, 30)
-
Specification