METHODS AND COMPOSITIONS FOR TREATING PAIN
First Claim
1. A pharmaceutical composition comprising an analgesic agent, a blood brain barrier (BBB) transport protein activator and a pharmaceutically acceptable excipient, wherein the analgesic agent is present in an amount sufficient to produce an analgesic effect, and wherein the BBB transport protein activator is present in an amount sufficient to reduce a central nervous system (CNS) effect of the analgesic agent.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
150 Citations
75 Claims
- 1. A pharmaceutical composition comprising an analgesic agent, a blood brain barrier (BBB) transport protein activator and a pharmaceutically acceptable excipient, wherein the analgesic agent is present in an amount sufficient to produce an analgesic effect, and wherein the BBB transport protein activator is present in an amount sufficient to reduce a central nervous system (CNS) effect of the analgesic agent.
- 32. A method of treating an animal for pain comprising administering to an animal in pain an effective amount of an analgesic agent and an amount of a BBB transport protein activator sufficient to reduce a central nervous system effect of the analgesic agent.
-
39. The method of 38 wherein the amount of analgesic agent administered is lower than the amount sufficient to produce an analgesic effect in the absence of administration of the BBB transport protein activator.
-
64. A method of controlling chronic pain comprising co-administering to an animal suffering from chronic pain
(i) an effective amount of an analgesic agent; - and
(ii) an amount of a BBB transport protein modulator sufficient to prevent or delay the development of tolerance to the analgesic agent in the animal. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
- and
Specification