Compositions and methods for enhancing immunity by chemoattractant adjuvants
First Claim
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1. An immunogenic composition, comprising:
- an antigen or immunogen;
at least one chemoattractant; and
a ligand for a Toll-like receptor (TLR).
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Abstract
The invention is directed to methods and compositions for enhancing immunity, including mucosal immunity. The compositions include an antigen or immunogen, a ligand for a Toll-like receptor and at least one chemoattractant.
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Citations
28 Claims
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1. An immunogenic composition, comprising:
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an antigen or immunogen;
at least one chemoattractant; and
a ligand for a Toll-like receptor (TLR). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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- 19. A method of enhancing immunity, comprising delivering to a subject an effective amount of a composition comprising an antigen, at least one chemoattractant, and a ligand for a Toll Like Receptor (TLR).
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25. A method for identifying an adjuvant compound that enhances immunity to an antigen or immunogen, comprising
delivering an immunogenic composition comprising the antigen or immunogen, at least one chemoattractant and a ligand for a Toll-like receptor to a subject; - and
measuring a level of immune response to the immunogenic composition, wherein the immune response is directed to the antigen or immunogen.
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- 26. A method of inducing a mucosal immunity, comprising applying to a mucosal membrane in a subject an effective amount of a composition comprising an antigen or immunogen, at least one chemoattractant, and a CpG.
Specification