System and method for coherent anti-stokes raman scattering endoscopy
First Claim
1. A system for detecting a signal field from a sample volume, said system comprising:
- a source system for providing a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency; and
an optical fiber system including at least one optical fiber for guiding said first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume, for receiving the signal field resulting from the coherent radiation, and for guiding the signal field to a detector.
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Abstract
A system is disclosed for detecting a signal field from a sample volume. The system includes a source system and an optical fiber system. The source system provides a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency. The optical fiber system includes at least one optical fiber for guiding the first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume. The optical fiber system also receives the signal field resulting from the coherent radiation, and guides the signal field to a detector.
77 Citations
27 Claims
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1. A system for detecting a signal field from a sample volume, said system comprising:
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a source system for providing a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency; and
an optical fiber system including at least one optical fiber for guiding said first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume, for receiving the signal field resulting from the coherent radiation, and for guiding the signal field to a detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A coherent anti-Stokes Raman scattering endoscopy system for detecting an anti-Stokes field induced by a non-linear interaction of a plurality of optical frequency components of at least one excitation pulse train in a sample volume, said system comprising:
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a source system including a coherent source for providing the plurality of optical frequency components of at least one excitation pulse train; and
an optical fiber system including at least one optical fiber for receiving an anti-Stokes field from the sample volume, and for guiding the anti-Stokes field to a detector using the at least one optical fiber in said optical fiber system, said anti-Stokes field being generated responsive to a non-linear coherent field generated by the interaction of said plurality of optical frequency components with the sample volume. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A coherent anti-Stokes Raman scattering endoscopy system for detecting an anti-Stokes field induced by a non-linear interaction of a pump field and a Stokes field in a sample volume, said system comprising:
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a source system for providing a pump electromagnetic field at a pump frequency and a Stokes electromagnetic field at a Stokes frequency that is different from the pump frequency;
a pump field and Stokes field optical fiber system including an optical fiber for guiding said pump and Stokes fields toward a lens as a single beam, said lens for directing said pump field and said Stokes field into the sample volume; and
an anti-Stokes field optical transmission system for receiving the anti-Stokes field from the sample volume, and for directing the anti-Stokes field to a detector, said anti-Stokes field being generated responsive to a non-linear coherent field generated by the interaction of said pump and Stokes fields in the sample volume. - View Dependent Claims (26, 27)
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Specification