IONTOPHORETIC DEVICE AND METHOD OF DELIVERY OF ACTIVE AGENTS TO BIOLOGICAL INTERFACE
First Claim
1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
- an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising;
a first compartment having a diluent;
a second compartment having an active agent; and
a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding.
5 Assignments
0 Petitions
Accused Products
Abstract
An iontophoresis device includes: an active electrode element operable to provide an electrical potential; an inner active agent reservoir comprising: a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding. The polymer complex is electrically responsive and disintegrates when an electrical field is applied. The active agent and the diluent become mixed to form a transient solution or dispersion prior to administration of the active agent
112 Citations
24 Claims
-
1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
-
an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising;
a first compartment having a diluent;
a second compartment having an active agent; and
a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A method for transdermal administration of an active agent by iontophoresis, comprising:
-
positioning an active electrode assembly and a counter electrode assembly of an iontophoresis device on a biological interface of a subject, the active electrode assembly further including an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising a first compartment having a diluent, a second compartment having an active agent, and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding; and
applying a sufficient amount of current to cause the polymer complex layer to disintegrate such that the diluent and the active agent are mixed, and to administer a therapeutically effective amount of the active agent in the subject for a limited period of time. - View Dependent Claims (22, 23, 24)
-
Specification