Iontophoresis device
First Claim
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1. An iontophoresis device used for administering an ionic active agent by iontophoresis comprising:
- an active electrode assembly comprising;
an active electrode;
an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir placed on an outer surface of the active electrode;
a second ion exchange membrane that selectively passes ions having a polarity opposite that of the ionic active agent, the second ion exchange membrane placed on an outer surface of the electrolyte solution reservoir;
an active agent reservoir that holds the ionic active agent, the active agent reservoir placed on an outer surface of the second ion exchange membrane; and
a first ion exchange membrane that selectively passes ions having the same polarity as the ionic active agent, the first ion exchange membrane placed on an outer surface of the active agent reservoir, a counter electrode assembly comprising a counter electrode; and
a DC electric power source connected to the active electrode of the active electrode assembly and to the counter electrode of the counter electrode assembly;
wherein the electrolyte solution reservoir and/or the active agent reservoir comprises a gel matrix that transforms to a liquid upon thermal excitation and/or mechanical excitation.
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Abstract
Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and/or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.
144 Citations
20 Claims
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1. An iontophoresis device used for administering an ionic active agent by iontophoresis comprising:
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an active electrode assembly comprising;
an active electrode;
an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir placed on an outer surface of the active electrode;
a second ion exchange membrane that selectively passes ions having a polarity opposite that of the ionic active agent, the second ion exchange membrane placed on an outer surface of the electrolyte solution reservoir;
an active agent reservoir that holds the ionic active agent, the active agent reservoir placed on an outer surface of the second ion exchange membrane; and
a first ion exchange membrane that selectively passes ions having the same polarity as the ionic active agent, the first ion exchange membrane placed on an outer surface of the active agent reservoir, a counter electrode assembly comprising a counter electrode; and
a DC electric power source connected to the active electrode of the active electrode assembly and to the counter electrode of the counter electrode assembly;
wherein the electrolyte solution reservoir and/or the active agent reservoir comprises a gel matrix that transforms to a liquid upon thermal excitation and/or mechanical excitation. - View Dependent Claims (2)
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3. An iontophoresis device used for administering an ionic active agent by iontophoresis, the iontophoresis device comprising:
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an active electrode assembly comprising;
an active electrode;
an active agent reservoir that holds the ionic active agent, the active agent reservoir positionable at least proximate a biological interface of a subject to transdermally deliver the ionic active agent to the biological interface; and
an electrolyte solution reservoir that holds an electrolyte solution, the electrolyte solution reservoir positioned between the active electrode and the active agent reservoir, wherein at least one of the electrolyte solution reservoir or the active agent reservoir comprises a gel matrix that transforms to a liquid upon excitation;
a counter electrode assembly comprising a counter electrode; and
a DC electric power source connected to the active electrode of the active electrode assembly and to the counter electrode of the counter electrode assembly, and operable to apply electrical potentials to the active and the counter electrodes. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification