STABILIZATION BY SUCTION USING MICRO-NEEDLES
First Claim
1. A device for permitting effective engagement of needles with a cutaneous layer thereby to permit for a substance to pass effectively to the cutaneous layer comprising:
- a) a first substrate of flexible material having a transverse area and a peripheral edge;
b) an array of needles arranged about the area for effectively engaging the cutaneous layer;
c) a bladder related to the substrate for acting on the substrate for causing proximal ends of the needles to pass to the cutaneous layer for passage of a substance associated with the needles to the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and with which the needles are connected, the surface area being for receiving and engaging the surface of the cutaneous layer with which the proximal ends of the needles are to pierce to effect a passage of a substance with the needles to the cutaneous layer, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) a connector for a suction generator for creating a suction force in the bladder thereby to urge the cutaneous layer towards the area within the peripheral edge of the material;
the arrangement being such that suction causes the needles and cutaneous layer to move relatively closer to each other and thereby permit the proximal ends of the needles to pierce the surface of the cutaneous layer, and permit the passage of a substance from the needles to the cutaneous layer.
1 Assignment
0 Petitions
Accused Products
Abstract
A device permits effective engagement of micro-needles with a cutaneous layer thereby to permit for a substance to pass effectively to the cutaneous layer. A flexible or non-flexible material supports an array of micro-needles for receiving the surface of the cutaneous layer so that the proximal ends of the micro-needles pierce to effect a passage of a substance with the micro-needles to the cutaneous layer. A passageway or bladder acts on the substrate to cause the proximal ends of the micro-needles to pass to the cutaneous layer for passage of a substance associated with the micro-needles to the cutaneous layer. The bladder includes apertures located about and spaced from the micro-needles such that suction transmitted though the apertures. The micro-needles are mounted with a movable first substrate. In one form, the first substrate includes a surface with concavities and the micro-needles are mounted in the concavities, and the apertures are located in the concavities. In another form the surface is substantially flat. There can be a third layer spaced relative to the second substrate layer at least partly forming a chamber between the second layer and third layer. There can be a biasing device for urging the first substrate from the cutaneous layer.
56 Citations
63 Claims
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1. A device for permitting effective engagement of needles with a cutaneous layer thereby to permit for a substance to pass effectively to the cutaneous layer comprising:
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a) a first substrate of flexible material having a transverse area and a peripheral edge;
b) an array of needles arranged about the area for effectively engaging the cutaneous layer;
c) a bladder related to the substrate for acting on the substrate for causing proximal ends of the needles to pass to the cutaneous layer for passage of a substance associated with the needles to the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and with which the needles are connected, the surface area being for receiving and engaging the surface of the cutaneous layer with which the proximal ends of the needles are to pierce to effect a passage of a substance with the needles to the cutaneous layer, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) a connector for a suction generator for creating a suction force in the bladder thereby to urge the cutaneous layer towards the area within the peripheral edge of the material;
the arrangement being such that suction causes the needles and cutaneous layer to move relatively closer to each other and thereby permit the proximal ends of the needles to pierce the surface of the cutaneous layer, and permit the passage of a substance from the needles to the cutaneous layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 35, 55, 56, 57, 63)
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13. A device for permitting effective engagement of needles with a cutaneous layer thereby to permit for a substance to pass effectively to the cutaneous layer comprising:
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a) a first substrate of material having a transverse area and a peripheral edge;
b) an array of needles arranged about the area for effectively engaging the cutaneous layer;
c) a passageway for transmitting suction pressure on the cutaneous layer, to cause proximal ends of the needles to pass to the cutaneous layer for passage of a substance associated with the needles to the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and with which the needles are connected, the surface area being for receiving and engaging the surface of the cutaneous layer with which the proximal ends of the needles are to pierce to effect a passage of a substance with the micro-needles to the cutaneous layer, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) a connector for a suction generator for creating a suction force thereby to urge the cutaneous layer towards the area within the peripheral edge of the material;
the arrangement being such that suction causes the needles and cutaneous layer to move relatively closer to each other and thereby permit the proximal ends of the needles to pierce the surface of the cutaneous layer; and
permit the passage of a substance from the needles to the cutaneous layer. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 36)
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26. A device for penetrating a cutaneous layer to permit for fluid to pass through the cutaneous layer comprising:
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a) a first substrate of material having an area and a peripheral edge;
b) an array of needles arranged about the area for piercing the cutaneous layer, the micro-needles having a proximal end and a distal end;
c) a bladder or drug cartridge for containing fluid for passing across the cutaneous layer for injection below the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and through which the needles are directed, and the surface area being for receiving and engaging the surface of the cutaneous layer about which the needles are to pierce to effect an injection of fluid, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) a connector for a suction generator for creating a suction force at the area thereby to urge the cutaneous layer towards the area within the peripheral edge of the material and thereby provide a stabilizing force to the cutaneous layer;
the arrangement being such that the needles and cutaneous layer are caused to move relatively closer to each other and thereby permit the proximal ends of the needles to pierce the surface of the cutaneous layer; and
permitting the expulsion of fluid from the bladder into the distal end of the needle and thereby permit the expulsion of fluid into the cutaneous layer. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 37)
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34. A device for penetrating a cutaneous layer to permit for fluid to pass through the cutaneous layer comprising:
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a) a first substrate of material having an area and a peripheral edge;
b) an array of needles arranged about the area for piercing the cutaneous layer, the needles having a proximal end and a distal end;
c) selectively a spring or electromagnetic system for causing the needles to move relatively with the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and through which the needles are directed, and the area being for receiving and engaging the surface of the cutaneous layer about which the micro-needles are to pierce to effect an injection of fluid, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) thereby to urge the cutaneous layer towards the area within the peripheral edge of the material and thereby provide a stabilizing force to the cutaneous layer;
the arrangement being such that the needles and cutaneous layer are caused to move relatively closer to each other and thereby permit the proximal ends of the needles to pierce the surface of the cutaneous layer; and
permitting the expulsion of fluid into the distal end of the needle and thereby permit the expulsion of fluid into the cutaneous layer. - View Dependent Claims (38)
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39. A device for permitting effective engagement of needles with a cutaneous layer thereby to permit for energy to pass effectively to the cutaneous layer comprising:
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a) a first substrate of flexible material having a transverse area and a peripheral edge;
b) an array of needles arranged about the area for effectively engaging the cutaneous layer;
c) a bladder related to the substrate for acting on the substrate for causing proximal ends of the needles to pass to the cutaneous layer for passage of energy associated with the needles to the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and with which the needles are connected being for receiving and engaging the surface of the cutaneous layer with which the proximal ends of the needles are to engage to effect a passage of energy with the needles to the cutaneous layer, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area; and
e) a connector for a suction generator for creating a suction force in the bladder thereby to urge the cutaneous layer towards the area within the peripheral edge of the material;
the arrangement being such that suction causes the needles and cutaneous layer to move relatively closer to each other and thereby permit the proximal ends of the needles to engage the surface of the cutaneous layer, and permit the passage of energy from the needles to the cutaneous layer. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 50, 51, 52, 54)
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49. A device for penetrating a cutaneous layer to permit for interaction with the cutaneous layer comprising:
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a) a first substrate of material having an area and a peripheral edge;
b) an array of needles arranged about the area for interacting with the cutaneous layer, the needles having a proximal end and a distal end;
c) selectively a spring or electromagnetic system for causing the needles to move relatively with the cutaneous layer;
d) a surface area transversely within peripheral edge of the material and through which the needles are directed, and the area being for receiving and engaging the surface of the cutaneous layer about which the micro-needles are to interact; and
e) thereby to urge the cutaneous layer towards the area within the peripheral edge of the material and thereby provide a stabilizing force to the cutaneous layer, and the layer thereby being stabilized against the engaging surface to thereby stabilize the cutaneous layer against the surface area;
the arrangement being such that the needles and cutaneous layer are caused to move relatively closer to each other and thereby permit the proximal ends of the needles to interact with the surface of the cutaneous layer; and
permitting the interaction of the distal end of the needle with the cutaneous layer. - View Dependent Claims (53, 58, 59, 60, 61, 62)
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Specification