Detection with evanescent wave probe
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Abstract
Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.
79 Citations
132 Claims
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1-96. -96. (canceled)
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97. A method for spatially resolved spin resonance spectroscopy in a material sample, the method comprising:
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exciting a sample with a first magnetic field, the first magnetic field having a field component along a first direction at a first location on the sample;
applying a second magnetic field to the sample, the second magnetic field having a field component along a second direction, the second direction being substantially perpendicular to the first direction, wherein the first magnetic field and the second magnetic field interact with at least one spin for at least one atomic constituent at the first location to produce a spin resonance; and
sensing the spin resonance of the at least one spin using a magnetic sensor located adjacent to the first location, wherein the magnetic sensor is sized to sense a sample volume of a micron3 or less and the spin resonance is nuclear magnetic resonance. - View Dependent Claims (98, 99, 100, 101, 102, 103, 104, 105, 106, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131)
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107. A system for making spatially resolved spin-resonance spectroscopic measurements in a material sample, comprising:
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a first magnetic field source, the first magnetic field source generating a first magnetic field in a sample region, wherein the first magnetic field has a field component along a first direction at a first location in the sample region;
a second magnetic field source, the second magnetic field source generating a second magnetic field in the sample region, the second magnetic field having a field component along a second direction in the sample region, the second direction being substantially perpendicular to the first direction, wherein the first and second magnetic fields interact with at least one spin of at least one atomic constituent of a sample at the first location to produce a spin resonance of the at least one spin; and
an magnetic sensor located adjacent to the first location, the magnetic sensor sensing the spin resonance of the at least one spin and generating a spin resonance signal, wherein the magnetic sensor is sized to sense a sample volume of micron3 or less and the spin resonance is nuclear magnetic resonance. - View Dependent Claims (108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119)
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132. (canceled)
Specification