Dissolution test equipment and methods for testing having improved filtration system
First Claim
1. A dissolution test apparatus comprising:
- a first chamber connected in series to at least a second chamber, wherein the first chamber is capable of transferring solid test samples to the second chamber and the second chamber is capable of retaining the solid test samples;
a first reservoir and at least a second reservoir for continuously supplying one or more media into the first chamber and the second chamber, respectively, the chambers having a stirrer for mixing the solid test samples and the media together;
wherein the second chamber has a filter membrane overlying a base of the second chamber, the filter membrane being supported by a filter support, the filter support being provided between the filter membrane and the base of the second chamber to prevent distortion of the filter membrane; and
a processor for analyzing an effluent from the chambers.
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Abstract
The present invention provides a dissolution test apparatus comprising, a first chamber 2 connected in series to at least a second chamber 10, wherein the first chamber 2 is capable of transferring solid test samples to the second chamber 10 and the second chamber 10 is capable of retaining the solid test samples. Further, the apparatus includes a first reservoir 21 and at least a second reservoir 22 for continuously supplying one or more media into the first chamber 2 and the second chamber 10, respectively, the chambers having stirrers 4, 11 for mixing the solid test samples and the media together. In addition, the second chamber 10 has a filter membrane 45 overlying a base 44 of the second chamber 10, the filter membrane 45 being supported by a filter support 46, the filter support 46 being provided between the filter membrane 45 and the base 44 of the second chamber 10 to prevent distortion of the filter membrane 45. Processors 5, 16, 20 for analyzing an effluent from the chambers are also provided.
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Citations
10 Claims
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1. A dissolution test apparatus comprising:
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a first chamber connected in series to at least a second chamber, wherein the first chamber is capable of transferring solid test samples to the second chamber and the second chamber is capable of retaining the solid test samples;
a first reservoir and at least a second reservoir for continuously supplying one or more media into the first chamber and the second chamber, respectively, the chambers having a stirrer for mixing the solid test samples and the media together;
wherein the second chamber has a filter membrane overlying a base of the second chamber, the filter membrane being supported by a filter support, the filter support being provided between the filter membrane and the base of the second chamber to prevent distortion of the filter membrane; and
a processor for analyzing an effluent from the chambers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A dissolution test apparatus comprising:
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a first chamber connected in series to at least a second chamber, wherein the first chamber is capable of transferring solid test samples to the second chamber and the second chamber is capable of retaining the solid test samples;
a first reservoir and at least a second reservoir for continuously supplying one or more media into the first chamber and the second chamber, respectively;
a filter membrane provided in a base of the first and second chambers, the base having ridges formed thereon;
a filter support provided over the ridges to prevent distortion of the filter membrane; and
a processor for analyzing an effluent from the chambers.
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10. A method for dissolution testing comprising:
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transferring solid test samples from a first chamber connected in series to at least a second chamber, wherein the second chamber is capable of retaining the solid test samples;
continuously supplying one or more media into the first chamber and the second chamber from a first reservoir and at least a second reservoir, respectively;
mixing the solid test samples and the media together;
filtering the solid test samples through a filter membrane supported by a filter support, the filter support overlying a base of the first and second chambers to prevent distortion of the filter membrane; and
analyzing an effluent from the chambers.
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Specification