METHOD OF DELIVERING CELLS TO THE SKIN

• US 20070092496A1
• Filed: 10/17/2006
• Published: 04/26/2007
• Est. Priority Date: 10/17/2005
• Status: Abandoned Application

• Current Assignee: Aderans Research Institute Incorporated
• Original Assignee: Aderans Research Institute Incorporated
• Inventors: Zheng, Ying, Stenn, Kurt, Du, Xiaobing, Washenik, Kenneth
• Application Number:
  US11/550,007
• Publication Number:
  US 20070092496A1
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61K 35/36 Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells islets of Langerhans A61K35/39
• CPC Class Codes: A61L 2430/18 for hair reconstruction
• CPC Class Codes: A61L 27/3813 Epithelial cells, e.g. keratinocytes, urothelial cells
• CPC Class Codes: A61L 27/3834 Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: C12N 5/0627 Hair cells
• CPC Class Codes: C12N 5/0629 Keratinocytes; Whole skin

Abstract

The present invention is a method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed from the hair follicle progenitor cells. The present invention is also a method of forming new skin comprising making a wound in the skin and placing skin forming cells on the wound, wherein new skin is formed from the skin forming cells.

Claims

1. A method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed.

2. The method of claim 1, wherein the cells comprise dermal cells.

3. The method of claim 1, wherein the cells comprise epidermal cells.

4. The method of claim 1, wherein the cells are placed in subepidermal skin.

5. The method of claim 1, wherein the cells are placed in papillary dermal skin.

6. The method of claim 1, wherein the cells are placed in upper reticular dermal skin.

7. The method of claim 1, wherein the wound is at least about 10 μ

m in depth.

8. The method of claim 1, wherein the wound is at least about 200 μ

m in depth.

9. The method of claim 1, wherein the wound is no more than about 500 μ

m in depth.

10. The method of claim 1, wherein the wound is no more than about 250 μ

m in depth.

11. The method of claim 1, further comprising covering the wound containing hair follicle progenitor cells with a wound dressing.

12. A method of forming new skin comprising making a wound in an area in need of new skin and placing skin forming cells on the wound, wherein new skin is formed.

13. The method of claim 12, wherein the cells comprise basal cells.

14. The method of claim 12, wherein the cells are placed in subepidermal skin.

15. The method of claim 12, wherein the cells are placed in papillary dermal skin.

16. The method of claim 12, wherein the cells are placed in upper reticular dermal skin.

17. The method of claim 12, wherein the wound is at least about 10 μ

m in depth.

18. The method of claim 12, wherein the wound is at least about 200 μ

m in depth.

19. The method of claim 12, wherein the wound is no more than about 500 μ

m in depth.

20. The method of claim 12, wherein the wound is no more than about 250 μ

m in depth.

21. The method of claim 12, further comprising covering the wound containing the skin forming cells with a wound dressing.