Water-soluble compound

• US 20070092549A1
• Filed: 02/23/2005
• Published: 04/26/2007
• Est. Priority Date: 10/31/2003
• Status: Abandoned Application

• Current Assignee: Technology Innovations, LLC
• Original Assignee: Technology Innovations, LLC
• Inventors: Goss, Kendrick, Curry, Stephen, Tuszynski, Jack, Greenwald, Howard
• Application Number:
  US11/063,441
• Publication Number:
  US 20070092549A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A water-soluble magnetic anti-mitotic compound with a water-solubility of at least 100 micrograms per milliliter, a molecular weight of at least 150 grams per mole, a mitotic index factor of at least 10 percent, a positive magnetic susceptibility of at least 1,000×10⁻⁶ cgs, and a magnetic moment of at least 0.5 bohr magnetrons, wherein said compound is comprised of at least 7 carbon atoms and at least one inorganic atom with a positive magnetic susceptibility of at least 200×10⁻⁶ cgs.

Claims

1. A process for treating a stent comprising the steps of

a. applying a magnetic field to a patient such that said magnetic field acts upon a stent wherein

i. said stent is disposed within a lumen of said patient, said stent having a first magnetic moment, said stent being further comprised of means to change said first magnetic moment to a second magnetic moment,

ii. said stent is comprised of a substrate wherein said substrate is comprised of a biologically active substrate and a magnetic moiety wherein:

1. said biologically active substrate is an anti-mitotic agent,

2. said magnetic moiety is covalently bound to said biologically active substrate, said magnetic moiety having a third magnetic moment,

iii. said third magnetic moment and said first magnetic moment are such that there is an attractive force between said stent and said substrate,

iv. said second magnetic moment and said first magnetic moment are such that there is a repulsive force between said stent and said substrate,

b. in response to said magnetic field, said first magnetic moment of said stent changes to said second magnetic moment, thereby causing said substrate to be repelled by said stent.

2. The process for treating a stent as recited in claim 1, wherein said stent is further comprised of plaque.

3. The process for treating a stent as recited in claim 2, wherein said biologically active substrate reduces the amount of said plaque.

4. The process for treating a stent as recited in claim 3, wherein said biologically active substrate is a taxane.

5. The process for treating a stent as recited in claim 4, wherein said taxane is a paclitaxel.

6. The process for treating a stent as recited in claim 5, said magnetic moiety is comprised of a iron atom with a positive magnetic susceptibility of at least 2×

10⁴ cgs,

7. A process for treating a stent comprising the steps of

a. applying a magnetic field to a patient such that said magnetic field acts upon a stent wherein

i. said stent is disposed within a lumen of said patient, said stent having a first magnetic moment, said stent being further comprised of means to change said first magnetic moment to a second magnetic moment,

ii. said stent is comprised of a substrate wherein said substrate is comprised of a biologically active substrate and a magnetic moiety wherein:

1. said biologically active substrate is an antimitotic agent,

2. said magnetic moiety is covalently bound to said biologically active substrate, said magnetic moiety having a third magnetic moment

iii. said third magnetic moment and said first magnetic moment are such that there Is a repulsive force between said stent and said substrate,

iv. said second magnetic and said first magnetic moment are such that there is an attractive force between said stent and said substrate,

b. in response to said magnetic field, said first magnetic moment of said stent changes to said second magnetic moment, thereby causing said substrate to be attracted to said stent.

8. The process for treating a stent as recited In claim 7, further comprising the step of administering a replenishment substrate to said lumen, wherein said replenishment substrate is comprised of a biologically active substrate and a magnetic moiety wherein;

a. said biologically active substrate is an anti-mitotic agent,

b. said magnetic moiety is covalently bound to said biologically active substrate, said magnetic moiety having a fourth magnetic moment,

c. said second magnetic and said fourth magnetic moment are such that there is an attractive force between said stent and said replenishment substrate.

9. The process for treating a stent as recited in claim 8, wherein, in response to said magnetic field, said first magnetic moment of said stent changes to said second magnetic moment, thereby causing said replenishment substrate to be attracted to said stent.

10. The process for treating a stent as recited in claim 9, wherein said stent is further comprised of a drug eluting polymer wherein said substrate is disposed within said drug eluting polymer.

11. The process for treating a stent as recited in claim 10, wherein said replenishment substrate becomes disposed within said drug eluting polymer by the action of said magnetic field.

12. The process for treating a stent as recited in claim 11, wherein said replenishment substrate and said substrate have the same molecular structure.

13. The process for treating a stent as recited in claim 12, wherein said lumen of said patient is a blood vessel.

14. A process for treating a stent comprising the steps of

a. applying a magnetic field to a patient such that said magnetic field acts upon a stent wherein

i. said stent is disposed within a lumen of said patient, said stent having a first magnetic moment, said stent being further comprised of means to change said first magnetic moment to a second magnetic moment,

ii. said stent is comprised of a substrate wherein said substrate is comprised of a biologically active substrate and a magnetic moiety wherein:

1. said biologically active substrate is a taxane,

2. said magnetic moiety is covalently bound to said biologically active substrate, said magnetic moiety having a third magnetic moment,

iii. said third magnetic moment and said first magnetic moment are such that there is an attractive force between said stent and said substrate,

iv. said second magnetic and said first magnetic moment are such that there is a repulsive force between said stent and said substrate,

b. in response to said magnetic field, said first magnetic moment of said stent changes to said second magnetic moment, thereby causing said substrate to be repelled by said stent.

15. The process for treating a stent as recited in claim 14, wherein

a. said magnetic moiety is comprised of a iron atom with a positive magnetic susceptibility of at least 2×

10<sup>−

4</sup> cgs, and

b. said substrate has a positive magnetic susceptibility of at least 1×

10<sup>−

3</sup> cgs.

16. The process for treating a stent as recited in claim 15, wherein said magnetic moiety is further comprised of a hydroxamic acid.

17. The process for treating a stent as recited in claim 16, wherein said hydroxamic acid is a ferrichrome.

18. The process for treating a stent as recited in claim 16, wherein said hydroxamic acid is a ferrioxamine.

19. The process for treating a stent as recited in claim 15, wherein said magnetic moiety is a siderophore.

20. The process for treating a stent as recited in claim 19, wherein said siderophore is a catecholate.