Diagnostic markers of hypertension and methods of use thereof
First Claim
1. A method of determining response to the pharmaceutical agent for hypertension, the method comprising:
- correlating (i) a mutational burden at one or more nucleotide positions in the AGT, ACE, AGTR1, CACNA1C, GPB, EDN1, EDN2, alpha-adducin, haptoglobin, CYP2C9, RGS2, ADRA1a, 11betaHSD2, ADRA1b, ADRA2A, ADRAB1, ADRAB2, REN, APOA, APOB, CETP, LIPC, EDNRB, or ENOS gene(s) in a sample from the subject with (ii) the mutational burden at one or more corresponding nucleotide positions in a control sample with known response outcome, and therefrom identifying the probability of response to said pharmaceutical agent.
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Abstract
The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific markers for hypertension treatment. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. Algorithms for determining proper treatment are disclosed. A diagnostic kit for a panel of said markers is disclosed. In various aspects, the invention provides methods for the early detection and differentiation of hypertension treatment. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.
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Citations
37 Claims
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1. A method of determining response to the pharmaceutical agent for hypertension, the method comprising:
- correlating (i) a mutational burden at one or more nucleotide positions in the AGT, ACE, AGTR1, CACNA1C, GPB, EDN1, EDN2, alpha-adducin, haptoglobin, CYP2C9, RGS2, ADRA1a, 11betaHSD2, ADRA1b, ADRA2A, ADRAB1, ADRAB2, REN, APOA, APOB, CETP, LIPC, EDNRB, or ENOS gene(s) in a sample from the subject with (ii) the mutational burden at one or more corresponding nucleotide positions in a control sample with known response outcome, and therefrom identifying the probability of response to said pharmaceutical agent.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
- 27. A kit comprising devices and reagents and a computer algorithm for measuring one or more mutational burdens of a patient and determining the diagnosis or prognosis in that patient for hypertension.
Specification