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AUTOMATED SAMPLE-TO-MICROARRAY SYSTEM

  • US 20070092901A1
  • Filed: 11/14/2006
  • Published: 04/26/2007
  • Est. Priority Date: 07/02/2004
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • a housing;

    a sample port for placing a liquid biological sample into the housing;

    a microarray port for inserting an oligonucleotide microarray into the housing;

    a lysis module within the housing and coupled to the sample port;

    a purification module within the housing coupled to the lysis module and capable of containing a solid phase for binding of oligonucleotides;

    a thermocycling module within the housing coupled to the purification module and capable of containing a polymerase chain reaction;

    a fragmentation module within the housing coupled to the thermocycling module; and

    a microarray module within the housing coupled to the fragmentation module and capable of holding the microarray and a liquid in contact with the microarray;

    wherein the apparatus is configured to be coupled to a device capable of;

    pumping a liquid through, in order, the lysis module, the purification module, the thermocycling module, the fragmentation module, and the microarray module;

    sonicating any contents of the lysis module;

    thermocycling the thermocycling module to perform the polymerase chain reaction;

    heating the fragmentation module to fragment any oligonucleotides contained therein;

    circulating a fluid over the surface of the microarray; and

    performing one or more washing or staining steps on the microarray.

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