IONTOPHORESIS DEVICE TO DELIVER MULTIPLE ACTIVE AGENTS TO BIOLOGICAL INTERFACES

• US 20070093787A1
• Filed: 09/29/2006
• Published: 04/26/2007
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Smith, Gregory
• Application Number:
  US11/537,006
• Publication Number:
  US 20070093787A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

An iontophoresis device includes active and counter electrode assemblies. The active electrode assembly includes an active electrode element and at least two laterally spaced active agent reservoirs. The active electrode assembly may also include an outermost ion selective membrane caching an active agent and a further active agent carried by an outer surface of the outermost ion selective membrane. The active electrode assembly may also include an electrolyte reservoir storing electrolyte and an inner ion selective membrane positioned between the electrolyte reservoir and the active agents. The active electrode may also include an inner withdrawable sealing liner between the electrolyte reservoir and the active agents. An outer release liner may protectively cover or overlay the further active agent and/or outer surface prior to use. The active electrode assembly may also include a blister pack of at least two hydrating agent blisters to selectively hydrate dehydrated active agent.

Claims

1. An iontophoresis device operable to deliver active agents to a biological interface of a biological entity, comprising:

an active electrode assembly, the active electrode assembly including a contact face exposed on an exterior of the active electrode to be proximate to a biological interface when in use, an active electrode element operable to apply a first electrical potential, a first active agent reservoir capable of storing a first active agent, at least a second active agent reservoir capable of storing a second active agent, an outermost ion selective membrane exposed to the exterior of the iontophoresis device to form an interface with the biological interface, the outermost ion selective membrane substantially permeable by ions having a first polarity that matches a polarity of the first and the second active agents, and substantially impermeable by ions of a second polarity, opposite the first polarity, at least a portion of the first and second active agent reservoirs formed in the outermost ion selective membrane, the second active agent reservoir spaced laterally in a plane approximately parallel to the contact face from the first active agent reservoir, at least the first and the second active agent reservoirs positioned with respect to the active electrode element to each actively transfer at least some of the first and the second active agents from the iontophoresis device to the biological interface in response to application of the first electrical potential; and

a counter electrode assembly spaced laterally from the active electrode assembly, the counter electrode assembly including a counter electrode element operable to apply a second electrical potential, the second electrical potential being different from the first electrical potential.

2. The iontophoresis device of claim 1 wherein the active electrode assembly further includes an electrolyte positioned between the active electrode element and the first and the second active agent reservoirs, and an inner ion selective membrane positioned between the electrolyte and the first and the second active agent reservoirs, the inner ion selective membrane selectively substantially permeable by ions having the second polarity and substantially impermeable by ions having the first polarity.

3. The iontophoresis device of claim 2 wherein the active electrode assembly further includes an inner sealing liner withdrawalably positioned between the electrolyte and the first and the second active agent reservoirs.

4. The iontophoresis device of claim 1, further comprising:

an outer release liner covering the first and the second active agents prior to use.

5. The iontophoresis device of claim 1 wherein the active electrode assembly further includes the first active agent stored in the first active agent reservoir and the second active agent stored in the second active agent reservoir.

6. The iontophoresis device of claim 5 wherein the first active agent is a first antigen and the second active agent is a second antigen, different from the first antigen.

7. The iontophoresis device of claim 1 wherein the active electrode assembly, further includes at least a third active agent reservoir capable of storing a third active agent, the third active agent reservoir spaced laterally in the plane approximately parallel to the contact face from the first and the second active agent reservoirs, the third active agent reservoir positioned with respect to the active electrode element to actively transfer at least some of the third active agent from the iontophoresis device to the biological interface in response to application of the first electrical potential.

8. The iontophoresis device of claim 7 wherein the first, the second and the third active agents each have the first polarity.

9. An active agent delivery system operable to deliver active agents to at least two distinct areas on a biological interface, the active agent delivery system, comprising:

an active electrode element operable to provide a first electrical potential; and

a retaining structure having at least two receptacles, each of the receptacles configured to securely receive a respective active agent reservoir, the receptacles spaced laterally with respect to each other to overlie respective ones of the distinct areas on the biological surface when the active agent delivery system is in use;

each of the receptacles at least partially underlying the active electrode element.

10. The active agent delivery system of claim 9, further comprising:

a first active agent reservoir configured to insertably secure within a first one of the receptacles; and

at least a second active agent reservoir configured to insertably secure within a second one of the receptacles.

11. The active agent delivery system of claim 10, further comprising:

at least a first active agent of a first polarity stored in the first active agent reservoir and substantially retained therein in the absence of an electromotive force or current and transferred outwardly in the presence of an electromotive force or current; and

at least a second active agent of the first polarity stored in the second active agent reservoir and substantially retained therein in the absence of an electromotive force or current and transferred outwardly in the presence of an electromotive force or current.

12. The active agent delivery system of claim 11 wherein the first and the second active agents are in dehydrated form prior to use.

13. The active agent delivery system of claim 12, further comprising:

a blister pack including at least two blisters of a hydrating agent, the blisters reputable to hydrate the first and the second active agents for use.

14. The active agent delivery system of claim 13 wherein the blisters are selectively reputable to hydrate selected ones of at least the first and the second active agents for use.

15. The active agent delivery system of claim 13 wherein the blister pack is positionable with respect to the receptacles.

16. The active agent delivery system of claim 13 wherein the blister pack is selectively positionable with respect to the receptacles to hydrate selected ones of at least the first and the second active agents for use.

17. The active agent delivery system of claim 13 wherein the retaining structure and blister pack are removably secured in place.

18. The active agent delivery system of claim 10, further comprising:

a blister pack including at least two blisters, each of the blisters holding a respective hydrating agent and a respective active agent, the blisters reputable to hydrate and load the active agents in the first and the second active agent reservoirs for use.

19. The active agent delivery system of claim 18 wherein the active agent in a first one of the blisters is different from the active agent in a second one of the blisters.

20. The active agent delivery system of claim 18 wherein the active agent in a first one of the blisters is a first antigen, and wherein the active agent in a second one of the blisters is a second antigen.

21. The active agent delivery system of claim 9, further comprising:

an electrolyte positioned between the active electrode element and the active agent receptacles.

22. The active agent delivery system of claim 9, further comprising:

an outermost ion selective membrane positioned to contact the biological interface when the active agent delivery system is in use.

23. An active agent delivery system, comprising:

an active electrode element operable to provide an electromotive force or current;

an outer ion selective membrane having an outer surface and at least two distinct regions laterally spaced from one another across the outer surface, each of the distinct regions having pores; and

at least two active agents of a first polarity cached within the pores of respective ones of the distinct regions of the ion selective membrane and substantially retained therein in the absence of the electromotive force or current and transferred outwardly from the ion selective membrane in the presence of the electromotive force or current.

24. The active agent delivery system of claim 23 wherein the outer ion selective membrane further has at least a third distinct region laterally spaced from the other distinct regions across the outer surface, and further comprising:

at least a third active agent of the first polarity cached within the pores of the third distinct region and substantially retained therein in the absence of the electromotive force or current and transferred outwardly from the ion selective membrane in the presence of the electromotive force or current.

25. The active agent delivery system of claim 24, further comprising:

a blister pack including at least two blisters of a hydrating agent, the blisters reputable to hydrate the active agents for use.

26. The active agent delivery system of claim 25 wherein the blisters are selectively reputable to hydrate selected ones of the active agents for use.

27. The active agent delivery system of claim 26 wherein the blister pack is positionable with respect to the distinct portions of the outmost ion selective membrane.

28. The active agent delivery system of claim 26 wherein the blister pack is selectively positionable with respect to the receptacles to hydrate selected ones of the active agents for use.

29. The active agent delivery system of claim 24, further comprising:

a blister pack including at least two blisters, each of the blisters holding a respective hydrating agent and a respective active agent, the blisters reputable to hydrate and load the active agents in the pores of the distinct regions of the ion selective membrane prior to use.

30. The active agent delivery system of claim 24 wherein the outmost ion selective membrane is an ion exchange membrane, the pores of the distinct regions containing an ion exchange material.