Agent for treating diabetes mellitus

• US 20070098680A1
• Filed: 04/15/2004
• Published: 05/03/2007
• Est. Priority Date: 04/15/2003
• Status: Active Grant

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Inventors: Kawabe, Yoshiki, Adachi, Yuichiro
• Granted Patent: US 7,662,366 B2
• Time in Patent Office: Days
• US Class Current: 424/85.1
• CPC Class Codes: A61K 38/193 Colony stimulating factors [CSF]
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The object of the present invention is to provide a method for treating diabetes which is simple, safe and effective when compared to conventional diabetes treatment. The administration of one or more stem cell-recruiting factors allows a simple and safe repair of disrupted β-cells in pancreatic Langerhans'"'"' islets. Thus, the therapeutic agent of the present invention which comprises one or more stem cell-recruiting factors as active ingredients is useful for diabetes treatment. Examples of such a stem cell-recruiting factor include colony-stimulating factors such as G-CSF.

Claims

1. An agent for treating diabetes, which comprises one or more stem cell-recruiting factors as active ingredients.

2-3. -3. (canceled)

4. An agent for regenerating β

-cells in pancreatic Langerhans'"'"' islets, which comprises one or more stem cell-recruiting factors as active ingredients.

5-6. -6. (canceled)

7. An agent for preventing β

-cell disruption in pancreatic Langerhans'"'"' islets, which comprises one or more stem cell-recruiting factors as active ingredients.

8-9. -9. (canceled)

10. A method for producing pancreatic Langerhans β

-cells, which comprises the steps of;

(a) collecting stem cells after administering one or more stem cell-recruiting factors; and

(b) differentiating the collected stem cells into pancreatic Langerhans β

-cells.

14. The method for producing pancreatic Langerhans β

-cells according to claim 10, wherein the stem cell-recruiting factor is a colony-stimulating factor.

11-13. -13. (canceled)