METHOD OF REPAIRING TISSUE OF A MAMMAL
First Claim
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1. A method of repairing tissue of a mammal comprising:
- administering to the mammal a therapeutically effective amount of a composition comprising peripheral blood stem cells, wherein the peripheral blood stem cells are in a number per volume that is at least seven times greater than in naturally-occurring peripheral blood and wherein the peripheral blood stem cells have a three dimensional geometry and cell-to-cell support and cell-to-cell geometry that is essentially the same as stem cells of naturally-occurring peripheral blood.
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Abstract
Method of treating disease or repairing tissue with compositions comprising mammalian peripheral blood stem cells, preferably CD34+/CD38− cells, and preferably peripheral blood stem cells resulting from TVEMF-expansion.
35 Citations
13 Claims
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1. A method of repairing tissue of a mammal comprising:
administering to the mammal a therapeutically effective amount of a composition comprising peripheral blood stem cells, wherein the peripheral blood stem cells are in a number per volume that is at least seven times greater than in naturally-occurring peripheral blood and wherein the peripheral blood stem cells have a three dimensional geometry and cell-to-cell support and cell-to-cell geometry that is essentially the same as stem cells of naturally-occurring peripheral blood. - View Dependent Claims (2)
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3. A method of repairing tissue of a mammal comprising:
administering to the mammal a therapeutically effective amount of a composition comprising TVEMF-expanded peripheral blood stem cells that are TVEMF-expanded and a pharmaceutically acceptable carrier. - View Dependent Claims (4, 5, 6, 7)
- 8. A method of treating a disease of a mammal comprising the step of administering to the mammal a therapeutically effective amount of a composition comprising the peripheral blood stem cells, wherein the peripheral blood stem cells are in a number per volume that is at least seven times greater than in naturally-occurring peripheral blood and wherein the peripheral blood stem cells have a three-dimensional geometry and cell-to-cell support and cell-to-cell geometry that is essentially the same as stem cells of naturally-occurring peripheral blood.
- 10. A method of treating a disease of a mammal comprising the step of administering to the mammal a therapeutically effective amount of a composition comprising peripheral blood stem cells and a pharmaceutically acceptable carrier, wherein the peripheral blood stem cells have been TVEMF-expanded.
Specification