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High throughput mobility shift

  • US 20070099200A1
  • Filed: 04/25/2006
  • Published: 05/03/2007
  • Est. Priority Date: 04/24/2002
  • Status: Active Grant
First Claim
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1. A method of detecting an interaction between a first molecule and at least a second molecule in a microfluidic device, the method comprising:

  • a) flowing a first labeled molecule with a first electrophoretic mobility, through at least a first microchannel;

    b) flowing at least a second molecule with a second electrophoretic mobility through the microchannel;

    c) applying a pulsed electric field through the microchannel, wherein the pulsed electric field separates the first and at least second molecule based upon the electrophoretic mobilities of the molecules; and

    , d) detecting a level of label or a level of signal from a label in the microchannel over a select time period.

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