Transdermal Electrotransport Delivery Device Including An Antimicrobial Compatible Reservoir Composition
First Claim
1. A transdermal electrotransport drug delivery or body analyte sampling device comprised of an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode, at least one of the anode and the cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material and an aqueous medium in contact with the housing, said aqueous medium comprised of (i) a drug or an electrolyte salt or a mixture thereof;
- (ii) propylene glycol; and
(iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium wherein the propylene glycol is present in an amount which renders the antimicrobial agent compatible with the device.
2 Assignments
0 Petitions
Accused Products
Abstract
A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
59 Citations
21 Claims
-
1. A transdermal electrotransport drug delivery or body analyte sampling device comprised of an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode, at least one of the anode and the cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material and an aqueous medium in contact with the housing, said aqueous medium comprised of (i) a drug or an electrolyte salt or a mixture thereof;
- (ii) propylene glycol; and
(iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium wherein the propylene glycol is present in an amount which renders the antimicrobial agent compatible with the device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 18, 19)
- (ii) propylene glycol; and
- 14. The transdermal electrotransport drug delivery or body analyte sampling device wherein said propylene glycol is present in a range of about 5% by weight to about 50% by weight.
-
20. A transdermal electrotransport drug delivery or body analyte sampling device, comprising:
- an anode;
a cathode, at least one of said anode and cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material;
a source of electrical power electrically connected to said anode and cathode; and
an aqueous medium in contact with said housing, said aqueous medium comprised of a drug or an electrolyte salt or a mixture thereof, propylene glycol and an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium, wherein the propylene glycol is present in an amount which renders the antimicrobial agent compatible with the device and said antimicrobial agent is present in a concentration at least about 0.005% by weight.
- an anode;
-
21. A transdermal electrotransport drug delivery or body analyte sampling device, comprising:
- an anode;
a cathode, at least one of said anode and cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material;
a source of electrical power electrically connected to said anode and cathode; and
an aqueous medium in contact with said housing, said aqueous medium comprised of a drug or an electrolyte salt or a mixture thereof, propylene glycol and an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium said antimicrobial agent being dissolved but is substantially neutral in charge in the presence of propylene glycol in the aqueous medium which is at pH from 5 to 8 when in operation.
- an anode;
Specification