Facilitation of endothelialization by in situ surface modification
First Claim
1. A method comprising:
- delivering to an treatment site within a lumen of a blood vessel by a percutaneous transluminal route at least one of (1) a cellular component comprising at least one of endothelial cells and endothelial progenitor cells and (2) a conjugate having a first site capable of conjugating with a wall of the blood vessel and a second site capable of conjugating with a cellular component.
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Accused Products
Abstract
A method including delivering to a treatment site within a lumen of a blood vessel (1) a cellular component including at least one of endothelial cells and endothelial progenitor cells and/or (2) a conjugate having a first site having affinity to or capable of conjugating with the blood vessel and a second site having affinity to a cellular component or capable of conjugating with a cellular component. A method including coating a treatment site within a lumen of a blood vessel with a polymeric biomaterial including (1) molecular moieties with affinity to cells or a treatment agent and (2) a treatment agent. A composition including a cellular component including endothelial cells or endothelial progenitor cells and modified to increase the potential for retention at a treatment site. A composition including a polymeric biomaterial including (1) molecular moieties with affinity to cells or a treatment agent or (2) a treatment agent.
25 Citations
39 Claims
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1. A method comprising:
delivering to an treatment site within a lumen of a blood vessel by a percutaneous transluminal route at least one of (1) a cellular component comprising at least one of endothelial cells and endothelial progenitor cells and (2) a conjugate having a first site capable of conjugating with a wall of the blood vessel and a second site capable of conjugating with a cellular component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method comprising:
coating a treatment site within a lumen of a blood vessel with a polymeric biomaterial comprising at least one of (1) molecular moieties with affinity to cells or a treatment agent and (2) a treatment agent. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A composition comprising:
an amount of a cellular component suitable for delivery into a blood vessel, the cellular component comprising at least one of endothelial cells and endothelial progenitor cells and is modified to increase the potential for retention at a treatment site within the blood vessel. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A composition comprising:
a polymeric biomaterial suitable for delivery into a blood vessel, the biomaterial comprising at least one of (1) molecular moieties with affinity to cells or a treatment agent and (2) a treatment agent. - View Dependent Claims (31, 32, 33, 34, 36, 37, 38, 39)
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35. The composition of 30, wherein the treatment agent is chemically conjugated to the biomaterial through a degradable conjugate.
Specification