Injectable soft tissue fixation technique

• US 20070100449A1
• Filed: 10/31/2005
• Published: 05/03/2007
• Est. Priority Date: 10/31/2005
• Status: Abandoned Application

• Current Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Inventors: Voellmicke, John, O'Neil, Michael, Cook, Alonzo
• Application Number:
  US11/262,904
• Publication Number:
  US 20070100449A1
• Time in Patent Office: Days
• US Class Current: 623/13.140
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/70 Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
• CPC Class Codes: A61B 17/8085 with pliable or malleable elements or having a mesh-like structure, e.g. small strips A61B17/8071, A61B17/8076 take precedence
• CPC Class Codes: A61B 17/84 Fasteners therefor or fasteners being internal fixation devices
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61L 2300/112 Phosphorus-containing compounds, e.g. phosphates, phosphonates
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

The present invention is directed toward a method for easily and securely attaching soft tissue graft materials to bone without puncturing the graft material and to provide for regeneration of bone removed for attachment.

Claims

1. A method for securing a soft tissue implant into bone comprising the steps of:

a) providing a hole in the bone;

b) inserting an end of the soft tissue implant into the hole; and

c) filling the hole with a curable material.

2. The method of claim 1, wherein the hole comprises an undercut.

3. The method of claim 1, wherein the soft tissue implant is a ligament.

4. The method of claim 1, wherein the soft tissue implant is a material selected from the group consisting of elastomeric polymers and extracellular matrices.

5. The method of claim 4 wherein the elastomeric polymers are selected from the group aliphatic polyesters, poly(amino acids), copoly(ether-esters), polyalkylenes oxalates, polyamides, tyrosine derived polycarbonates, poly(iminocarbonates), polyorthoesters, polyoxaesters, polyamidoesters, polyoxaesters containing amine groups, poly(anhydrides), polyphosphazenes, poly(propylene fumarate), polyurethane, poly(ester urethane), poly(ether urethane), and blends and copolymers thereof.

6. The method of claim 5, wherein the elastomeric polymer is selected form the group consisting of ε

-caprolactone, glycolide, lactide, p-dioxanone, trimethylene carbonate and combinations thereof.

7. The method of claim 4, wherein the extracellular matrix is selected form the group consisting of small intestine submucosa, stomach, bladder, alimentary, respiratory, genital submucosa, liver basement membrane and combinations thereof.

8. The method of claim 4, wherein the extracellular matrix is small intestine submucosa.

9. The method of claim 1, wherein the curable material is selected form the group consisting of bone cements, resorbable or non-resorbable polymers, tissue adhesives, and biological adhesives

10. The method of claim 1, wherein the curable material comprises polypropylene fumarate or polymethyl methacrylate (PMMA) combined with a cross-linking agent.

11. The method of claim 1, wherein the curable material comprises a thermoplastic or thermosetting polymer.

12. The method of claim 1, wherein the curable material comprises a polymer of polyamino acid or polyanhydride.

13. The method of claim 12, wherein the curable material further comprises tricalcium phosphate, calcium sulfate or hollow PMMA microspheres.

14. The method of claim 1, wherein the curable material comprises a UV curable polymer.

15. The method of claim 9, wherein the curable material further comprises a bioactive agent which acts as an osteogenic agent and is selected from the group consisting of hydroxyapatite, tricalcium phosphate, ceramic glass, amorphous calcium phosphate, porous ceramic particles or powders, demineralized bone particles or powder, transforming growth factors, growth differentiation factors, bone morphogenic proteins, recombinant human growth factors, cartilage-derived morphogenic proteins and combinations thereof.

16. The method of claim 15, wherein the bioactive agent is BMP-2.

17. The method of claim 15, wherein the bioactive agent is BMP-7

18. The method of claim 15, wherein the bioactive agent is rhGDF-5.

19. The method of claim 15, wherein the bioactive agent is hydroxyapatite.

20. The method of claim 15 wherein, the bioactive agent is tricalcium phosphate.

21. The method of claim 1, wherein step c) further comprises inserting into the hole a coil or spring along with the end of the implant.

22. The method of claim 1, wherein step c) further comprises inserting into the hole a shape memory device along with the end of the implant.