Particles that disrupt or impede bacterial adhesion, related compositions and methods

• US 20070104660A1
• Filed: 11/10/2005
• Published: 05/10/2007
• Est. Priority Date: 11/10/2005
• Status: Active Grant

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Xu, Tao, Trivedi, Harsh, Miksa, Davide
• Granted Patent: US 8,119,162 B2
• Time in Patent Office: Days
• US Class Current: 424/49
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/732 Starch; Amylose; Amylopectin; Derivatives thereof
• CPC Class Codes: A61K 8/735 Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• CPC Class Codes: A61K 8/736 Chitin; Chitosan; Derivatives thereof
• CPC Class Codes: A61K 8/8129 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/87 Polyurethanes
• CPC Class Codes: A61K 8/88 Polyamides
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Oral care and other compositions comprising particles having cores attached to bioadhesive polymers for inhibition of pellicle formation, plaque formation, biofilm formation, biofouling, and microbial adhesion or attachment are described. Methods using said compositions to treat surfaces, such as oral surfaces.

Claims

1. A particle comprising

a core comprising an oxide compound or its salt and

a bioadhesive polymer,

wherein the bioadhesive polymer is attached to the oxide compound or its salt.

2. The particle according to claim 1, wherein the bioadhesive polymer is selected from a polysaccharide or related polymer, a polypeptide, a polyanhydride polymer, or a polycarboxylate polymer.

3. The particle according to claim 1, wherein the bioadhesive polymer is selected from a polysaccharide or related polymer and a polycarboxylate polymer.

4. The particle according to claim 1, wherein the bioadhesive polymer is selected from a substituted or unsubstituted poly(saccharide) polymer, poly(deoxysaccharide) polymer;

poly(sugar acid) polymer, poly(sugar alcohol) polymer, an acrylic or other poly-acid polymer, and a carboxyalkylpolysaccharide.

5. The particle according to claim 1, wherein the bioadhesive polymer is selected from a cellulose, a chitosan, a starch, a glycogen, a substituted saccharide polymer, and a microbial exudate.

6. The particle according to claim 1, wherein the bioadhesive polymer is selected from a polysaccharide gum and a glycosaminoglycan.

7. The particle according to claim 1, wherein the bioadhesive polymer is selected from a dextran and a hyaluronate.

8. The particle according to claim 1, wherein the oxide compound or salt of the core is selected from a metal oxide, a non-metal oxide, a semi-metal oxide and a salt therof.

9. The particle according to claim 8, wherein the oxide or salt is selected from a metal carbon oxide, a metal phosphorus oxide, a metal sulfur oxide, and a metal silicate.

10. The particle according to claim 9, wherein the oxide compound is a simple oxide compound.

11. The particle according to claim 10, wherein the simple oxide compound is selected from SiO₂ and ZnO.

12. The particle according to claim 9, wherein the oxide compound is selected from an alkaline earth metal carbonate, an alkaline earth metal phosphate, and an alkaline earth metal sulfate.

13. The particle according to claim 1, wherein the bioadhesive polymer is attached to the oxide compound or salt by a linker.

14. The particle according to claim 13, wherein the linker is selected from a bond and linker molecule.

15. A composition comprising particles according to claim 1 and a carrier.

19. A method for inhibiting or reducing the formation of plaque on an oral surface comprising contacting the oral surface with a particle according to claim 1.

20. A method for inhibiting or reducing the attachment of bacteria on an oral surface comprising contacting the oral surface with a particle according to claim 1.

21. A method for maintaining or promoting the systemic health in a mammal comprising applying the particles according to claim 1 to an oral surface.

22. A method for inhibiting or reducing deposition of biofilm or attachment of microbes to an oral surface comprising contacting the surface with a particle according to claim 1.

16. A process for preparing a particle comprising attaching a bioadhesive polymer to an oxide core, thereby obtaining a particle.

17. The process according to claim 16, wherein the bioadheisve polymer is attached to the core by at least one omega-aminoaliphatyl-tri(aliphatoxy)silane molecule.

18. The process according to claim 16, wherein the omega-aminoaliphatyl-tri(aliphatoxy)silane molecule is selected from 3-aminopropyltriethoxysilane, 3-aminopropyltrimethoxysilane, 2-aminoethyltrimethoxysilane, and 2-aminoethyltriethoxysilane.