Breast augmentation system

• US 20070104693A1
• Filed: 11/07/2005
• Published: 05/10/2007
• Est. Priority Date: 11/07/2005
• Status: Abandoned Application

• Current Assignee: Junomedica, Inc.
• Original Assignee: Junomedica, Inc.
• Inventors: Tu, Hosheng, Quijano, Rodolfo, Williams, Kenneth, Carter, Robert, Nguyen, Tuoc
• Application Number:
  US11/268,432
• Publication Number:
  US 20070104693A1
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3895 using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
• CPC Class Codes: C12N 2539/10 Coating allowing for selective detachment of cells, e.g. thermoreactive coating
• CPC Class Codes: C12N 5/0667 Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Abstract

A stem-cell-seeded porous scaffold implant and delivery systems for treating or augmenting a breast tissue defect in a patient.

Claims

1. A breast matrix system for treating a breast defect of a patient, comprising an implantable breast matrix and stem cells component, wherein stem cells are derived from adipose tissue.

2. The breast matrix system of claim 1, wherein the breast matrix comprises a fishbone configuration, the fishbone-configured breast matrix being characterized by an expandable construct with a plurality of close cells formed between longitudinal elements and connecting transverse elements.

3. The breast matrix system of claim 2, further comprising a delivery instrument for delivering said fishbone-configured breast matrix to a breast of the patient for treating the breast defect.

4. The breast matrix system of claim 1, wherein the breast matrix comprises an umbrella configuration, the umbrella-configured breast matrix being characterized by a plurality of radially expandable extending elements, each extending element having a distal end and a proximal end, wherein the proximal ends from all extending elements are secured together at one point.

5. The breast matrix system of claim 4, further comprising a delivery instrument for delivering said umbrella-configured breast matrix to a breast of the patient for treating the breast defect.

6. The breast matrix system of claim 1, wherein the breast matrix comprises a wrap-around configuration, the wraparound-configured breast matrix being made of shape memory material and characterized by a first pre-implant low-profile configuration at a lower temperature and a second implanted configuration at a higher temperature.

7. The breast matrix system of claim 6, wherein said shape memory material is biodegradable polymer.

8. The breast matrix system of claim 6, wherein said shape memory material is Nitinol.

9. The breast matrix system of claim 1, wherein the breast matrix comprises a yo-yo configuration, the yoyo-configured breast matrix being characterized by a plurality of circular rings with varying diameters, wherein at least two circular rings are releasably secured to each other by a circular semi-ring to form an overall bowl-like configuration.

10. The breast matrix system of claim 1, wherein the breast matrix is biodegradable or bioresorbable.

11. The breast matrix system of claim 1, wherein the breast defect is traumatically created by a process of inserting said breast matrix into a breast of the patient.

12. The breast matrix system of claim 1, wherein the stem cells portion comprise breast tissue progenitor cells.

13. The breast matrix system of claim 12, further comprising a medium for containing said stem cells or breast tissue progenitor cells.

14. The breast matrix system of claim 13, wherein the medium comprises at least one growth factor selected from a group consisting of transforming growth factor-β

, insulin-like growth factor, platelet derived growth factor, epidermal growth factor, acidic fibroblast growth factor, basic fibroblast growth factor, and hepatocytic growth factor.

15. The breast matrix system of claim 13, wherein the medium comprises at least one nutrient selected from a group consisting of vitamin A, retinoic acid, vitamin B series, and vitamin C.

16. A delivery instrument for delivering an umbrella-configured breast matrix to a breast of a patient comprising:

a hollow tubular sheath having a distal tip, a lumen having an opening at the distal tip, and a handle portion;

a plunger inside the lumen, wherein the plunger is activated by a pushing mechanism located at the handle portion; and

wherein the lumen is sized and configured for appropriately receiving an umbrella-configured breast matrix at a collapsed profile.

17. The delivery instrument of claim 16, wherein the umbrella-configured breast matrix being characterized by a plurality of radially expandable extending elements, each extending element having a distal end and a proximal end, wherein the proximal ends from all extending elements are secured together at one point.

18. A delivery instrument for delivering an umbrella-configured breast matrix to a breast of a patient comprising a tubular applicator having a distal tip, a distal portion and a handle portion, wherein the distal portion is sized and configured for appropriately receiving an umbrella-configured breast matrix at a collapsed profile over the distal portion.

19. The delivery instrument of claim 18, wherein the umbrella-configured breast matrix being characterized by a plurality of radially expandable extending elements, each extending element having a distal end and a proximal end, wherein the proximal ends from all extending elements are secured together at one point.

20. The delivery instrument of claim 19, wherein the umbrella-configured breast matrix further comprises at least one connecting member between any two extending elements, wherein the connecting member is selected from a group consisting of netting, strings, threads, porous membranes, and porous biodegradable films.