Chemical array housing having a gas delivery element and methods of using the same

• US 20070105125A1
• Filed: 11/08/2005
• Published: 05/10/2007
• Est. Priority Date: 11/08/2005
• Status: Abandoned Application

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Tsai, George, McMillan, Jeffrey
• Application Number:
  US11/270,764
• Publication Number:
  US 20070105125A1
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: B01L 2300/0609 Holders integrated in container to position an object
• CPC Class Codes: B01L 2300/0803 Disc shape
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2300/0822 Slides
• CPC Class Codes: B01L 9/52 Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips

Abstract

Chemical array housings configured for use with chemical array readers are provided, where the housings include at least one chemical array holding element and a gas delivery element. Aspects of the invention include positioning a chemical array in the housing and introducing a gas into the housing. Also provided are chemical array readers that include housings of the present invention. The subject devices and methods find use in a variety of different applications, including chemical array reading applications.

Claims

1. A chemical array housing, comprising:

at least one chemical array holding element; and

a gas delivery element for introducing a gas into said housing;

wherein said chemical array housing is configured to be used with an array reader.

2. The chemical array housing according to claim 1, wherein said housing comprises multiple chemical array holding elements.

3. The chemical array housing according to claim 1, wherein said chemical array holding element is configured to receive an array present in an array holder.

4. The chemical array housing according to claim 1, wherein said chemical array housing comprises a container element and a lid element.

5. The chemical array housing according to claim 4, wherein said lid element comprises an opening configured to provide for transfer of a chemical array into and out of said housing.

6. The chemical array housing according to claim 1, wherein said housing has a carousel configuration.

7. The chemical array housing according to claim 1, wherein said gas delivery element comprises a gas diffuser.

8. The chemical array housing according to claim 7, wherein said gas diffuser extends along at least a portion of an interior surface of said housing.

9. The chemical array housing according to claim 8, wherein said housing comprises a lid element and said diffuser extends along a least a portion of an interior surface of said lid element.

10. The chemical array housing according to claim 1, wherein said housing further comprises a valve that controls gas flow into said gas delivery element.

11. The chemical array housing according to claim 1, wherein at least one chemical array is present in a holder of said housing.

12. The chemical array housing according to claim 1, wherein said chemical array housing comprises substantially no ozone.

13. The chemical array housing according to claim 12, wherein said housing comprises nitrogen gas.

14. The chemical array housing according to claim 1, wherein said housing is configured to house 48 slides.

15. The chemical array housing according to claim 14, wherein said slides are each about 25 mm wide and about 75 mm long.

16. The housing according to claim 1, wherein said housing is configured for being removably positioned inside of said reader.

17. A chemical array reader comprising a housing according to claim 1.

18. The chemical array reader according to claim 17, wherein said housing is present inside of said reader.

19. The chemical array reader according to claim 18, further comprising a gas conveyer element for conveying gas to said gas delivery element of said housing.

20. The chemical array reader according to claim 19, wherein said gas conveyer element comprises tubing.

21. The chemical array reader according to claim 20, wherein said tubing is perforated.

22. The chemical array reader according to claim 20, wherein said gas conveyer element further comprises connectors for connecting said tubing to an external gas source.

23. The chemical array reader according to claim 22, wherein said gas conveyer element further comprises a valve.

24. The chemical array reader of claim 17, further comprising programming for regulating the delivery of gas into said housing.

25. The chemical array reader of claim 17, further comprising a sensor for detecting the presence of a gas in said housing.

26. A method for reading a chemical array, said method comprising:

a) providing a chemical array reader that comprises a housing according to claim 1 that includes a chemical array; and

b) reading said chemical array with said chemical array reader.

27. The method according to claim 26, wherein said method further comprises introducing an ozone free gas into said housing through said gas delivery element of said housing.

28. The method of claim 27, wherein said ozone free gas is nitrogen.

29. The method according to claim 27, wherein said ozone free gas is compressed air that has had ozone removed from it by activated charcoal filter.

30. A kit comprising a housing according to claim 1.

31. The kit according to claim 30, wherein said kit further comprises a gas conveyer element for conveying gas from an external source to said housing.

32. A chemical array housing lid element, wherein said lid element comprises:

a) a lid configured for at least partially enclosing a chemical array container element, wherein said container element includes at least one chemical array holding element; and

b) a gas delivery element.

33. The chemical array housing lid element of claim 32, wherein said container element comprises a chemical array carousel.

34. The chemical array housing lid element of claim 33, wherein said gas delivery element comprises an opening configured for receiving a gas conveyer element.

35. The chemical array housing lid element of claim 34, wherein said gas conveyer element comprises tubing.

36. The chemical array housing lid element of claim 32, wherein said lid element further comprises a slot element configured for facilitating the delivery of a chemical array from said chemical array holding element to a chemical array reader.