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Splice switch oligomers for TNF superfamily receptors and their use in treatment of disease

  • US 20070105807A1
  • Filed: 11/10/2006
  • Published: 05/10/2007
  • Est. Priority Date: 11/10/2005
  • Status: Abandoned Application
First Claim
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1. A method of treating an inflammatory disease or condition which comprises administering one or more splice switching oligomers (SSOs) to a subject for a time and in an amount to reduce the activity of a ligand for a receptor of the tumor necrosis factor receptor (TNFR) superfamily, wherein said one or more SSOs are capable of altering the splicing of a pre-mRNA encoding said receptor to increase production of a stable, secreted, ligand-binding form of said receptor.

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