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Dietary Control of Arachidonic Acid Metabolism

  • US 20070105957A1
  • Filed: 11/14/2006
  • Published: 05/10/2007
  • Est. Priority Date: 02/23/1998
  • Status: Active Grant
First Claim
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1. A method of treating an inflammatory disorder, or a disorder having an inflammatory component, in a mammalian subject in need of such treatment by administering to said subject an effective amount of a composition in unit dosage form for delivery of a daily dose of said composition, said composition consisting essentially of:

  • (i) an effective amount of γ

    -linolenic acid (GLA) for increasing dihomogammalinolenic acid (DGLA) levels in the inflammatory cells of said mammalian subject, thereby inhibiting the metabolism of arachidonic acid;

    (ii) an effective amount of a Δ

    5 desaturase inhibitor for inhibiting accumulation of arachidonic acid in the serum of said mammalian subject; and

    , optionally, (iii) an effective amount of a competitive inhibitor of arachidonic acid metabolism.

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